HuLPr23950

Uniprot ID

GGCT_HUMAN

Uniprot Acc

O75223;B2RDN0;Q9BS37;

Protein name

Gamma-glutamylcyclotransferase

Comment

FUNCTION:Catalyzes the formation of 5-oxoproline from gamma- glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis.||CATALYTIC ACTIVITY:(Gamma-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid.||BIOPHYSICOCHEMICAL PROPERTIES:Kinetic parameters: KM=2.0 mM for gamma-glutamyl-L-alanine; Vmax=50.3 umol/min/mg enzyme;||SUBUNIT:Homodimer (Probable).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O75223-1; Sequence=Displayed; Name=2; IsoId=O75223-2; Sequence=VSP 035599, VSP 035600; Note=No experimental confirmation available;||INDUCTION:By geranylgeraniol.||SIMILARITY:Belongs to the gamma-glutamylcyclotransferase family.

Gene name

gamma-glutamylcyclotransferase

Protein sequence

MANSGCKDVTGPDEESFLYFAYGSNLLTERIHLRNPSAAF FCVARLQDFKLDFGNSQGKTSQTWHGGIATIFQSPGDEV WGVVWKMNKSNLNSLDEQEGVKSGMYVVIEVKVATQEGK EITCRSYLMTNYESAPPSPQYKKIICMGAKENGLPLEYQ EKLKAIEPNDYTGKVSEEIEDIIKKGETQTL

Database cross reference

RefSeq Protein accession:NP_001186744
RefSeq Protein gi:315360618

HLPP validation

Yes/No

Yes

Project name

French Liver;Chinese Liver;Human Fetal Liver;Human Liver Organelles;

GO:0005829;C:cytosol;IDA:UniProtKB.

GO-F

GO:0008415;F:acyltransferase activity;IEA:UniProtKB-KW. GO:0003839;F:gamma-glutamylcyclotransferase activity;IDA:UniProtKB. GO:0042803;F:protein homodimerization activity;IDA:UniProtKB.

GO-P

GO:0001836;P:release of cytochrome c from mitochondria;IMP:UniProtKB.

Glutathione_Metabolism