Protein basic information
| LiverAtlas Protein ID |
HuLPr23963 |
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Uniprot ID |
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Uniprot Acc |
Q6P531;B4DUH4;Q8NCM0; |
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Protein name |
Gamma-glutamyltransferase 6 |
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Comment |
FUNCTION:Cleaves glutathione conjugates (By similarity).||CATALYTIC ACTIVITY:(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid.||PATHWAY:Sulfur metabolism; glutathione metabolism.||SUBUNIT:Heterodimer composed of the light and heavy chains. The active site is located in the light chain (By similarity).||SUBCELLULAR LOCATION:Membrane; Single-pass type II membrane protein (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6P531-1; Sequence=Displayed; Name=2; IsoId=Q6P531-2; Sequence=VSP 030451;||SIMILARITY:Belongs to the gamma-glutamyltransferase family. |
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Subcellular localization |
Membrane;Single-pass type II membrane protein(By similarity). |
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Gene name |
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Protein sequence
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MERAEEPVVYQKLLPWEPSLESEEEVEEEETSEALVLNPR RHQDSSRNKAGGLPGTWARVVAALLLLAVGCSLAVRQLQ NQGRSTGSLGSVAPPPGGHSHGPGVYHHGAIISPAGREL LVAGGNVVDAGVGAALCLAVVHPHATGLGAMFWGLFHDS SSGNSTALTSGPAQTLAPGLGLPAALPTLHLLHARFGRL PWPRLLVGPTTLAQEGFLVDTPLARALVARGTEGLCPLL CHADGTPLGAGARATNPQLAAVLRSAALAPTSDLAGDAL LSLLAGDLGVEVPSAVPRPTLEPAEQLPVPQGILFTTPS PSAGPELLALLEAALRSGAPIPDPCPPFLQTAVSPESSA LAAVDSSGSVLLLTSSLNCSFGSAHLSPSTGVLLSNLVA KSTTSAWACPLILRGSLDDTEADVLGLVASGTPDVARAM THTLLRHLAARPPTQAQHQHQGQQEPTEHPSTCGQGTLL QVAAHTEHAHVSSVPHACCPFQGF |
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Database cross reference |
RefSeq Protein accession:NP_001116362
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. |
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GO-F |
GO:0008415;F:acyltransferase activity;IEA:UniProtKB-KW. GO:0003840;F:gamma-glutamyltransferase activity;IEA:EC. |
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GO-P |
GO:0006750;P:glutathione biosynthetic process;IEA:UniProtKB-KW. |
Pathway
| Pathway name | |
| Pathway name | |
| Pathway name | |
| Pathway name |
