HuLPr23964

Uniprot ID

GGT7_HUMAN

Uniprot Acc

Q9UJ14;Q8N899;Q8NF66;Q9BYP5;Q9BYP6;

Protein name

Gamma-glutamyltransferase 7

Comment

FUNCTION:Cleaves glutathione conjugates (By similarity).||CATALYTIC ACTIVITY:(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid.||PATHWAY:Sulfur metabolism; glutathione metabolism.||SUBUNIT:Heterodimer composed of the light and heavy chains. The active site is located in the light chain (By similarity). Isoform 3 interacts with FAM57A.||SUBCELLULAR LOCATION:Membrane; Single-pass type II membrane protein (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=a; IsoId=Q9UJ14-1; Sequence=Displayed; Note=Gene prediction confirmed by EST data; Name=2; IsoId=Q9UJ14-4; Sequence=VSP 008134, VSP 008138, VSP 008139; Note=No experimental confirmation available; Name=3; Synonyms=GGTL3B, B; IsoId=Q9UJ14-5; Sequence=VSP 008136, VSP 008137; Name=4; IsoId=Q9UJ14-6; Sequence=VSP 008133, VSP 008140, VSP 008141; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Widely expressed, but at low level, except in

Subcellular localization

Membrane;Single-pass type II membrane protein(By similarity).

Gene name

gamma-glutamyltransferase 7

Protein sequence

MAAENEASQESALGAYSPVDYMSITSFPRLPEDEPAPAAP LRGRKDEDAFLGDPDTDPDSFLKSARLQRLPSSSSEMGS QDGSPLRETRKDPFSAAAAECSCRQDGLTVIVTACLTFA TGVTVALVMQIYFGDPQIFQQGAVVTDAARCTSLGIEVL SKQGSSVDAAVAAALCLGIVAPHSSGLGGGGVMLVHDIR RNESHLIDFRESAPGALREETLQRSWETKPGLLVGVPGM VKGLHEAHQLYGRLPWSQVLAFAAAVAQDGFNVTHDLAR ALAEQLPPNMSERFRETFLPSGRPPLPGSLLHRPDLAEV LDVLGTSGPAAFYAGGNLTLEMVAEAQHAGGVITEEDFS NYSALVEKPVCGVYRGHLVLSPPPPHTGPALISALNILE GFNLTSLVSREQALHWVAETLKIALALASRLGDPVYDST ITESMDDMLSKVEAAYLRGHINDSQAAPAPLLPVYELDG APTAAQVLIMGPDDFIVAMVSSLNQPFGSGLITPSGILL NSQMLDFSWPNRTANHSAPSLENSVQPGKRPLSFLLPTV VRPAEGLCGTYLALGANGAARGLSGLTQVLLNVLTLNRN LSDSLARGRLHPDLQSNLLQVDSEFTEEEIEFLEARGHH VEKVDVLSWVHGSRRTNNFIIAVKDPRSPDAAGATIL

Database cross reference

RefSeq Protein accession:NP_821158
RefSeq Protein gi:109148539

HLPP validation

Yes/No

Yes

Project name

French Liver;Human Fetal Liver;Human Liver Organelles;

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW.

GO-F

GO:0008415;F:acyltransferase activity;IEA:UniProtKB-KW. GO:0003840;F:gamma-glutamyltransferase activity;IEA:EC.

GO-P

GO:0006750;P:glutathione biosynthetic process;IEA:UniProtKB-KW.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr23964

PHOSPHORYLATION

72

S

PhosphoSitePlus

472448

LTP

HTP

N

HuLPr23964

PHOSPHORYLATION

73

S

PhosphoSitePlus

5038394

LTP

N

HuLPr23964

PHOSPHORYLATION

75

S

PhosphoSitePlus

5038399

LTP

N