Protein basic information
| LiverAtlas Protein ID |
HuLPr24050 |
|
Uniprot ID |
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Uniprot Acc |
Q86SR1;B3KXC9;Q6IN56;Q86VP8;Q8IXJ2;Q8TEJ2;Q96IV2;Q9H8E1;Q9Y4M4; |
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Protein name |
Polypeptide N-acetylgalactosaminyltransferase 10 |
|
Comment |
FUNCTION:Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward Muc5Ac and EA2 peptide substrates.||CATALYTIC ACTIVITY:UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide.||COFACTOR:Manganese (By similarity).||COFACTOR:Calcium (By similarity).||PATHWAY:Protein modification; protein glycosylation.||SUBCELLULAR LOCATION:Golgi apparatus membrane; Single-pass type II membrane protein (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q86SR1-1; Sequence=Displayed; Name=2; IsoId=Q86SR1-2; Sequence=VSP 011209; Note=No experimental confirmation available; Name=3; IsoId=Q86SR1-3; Sequence=VSP 011212, VSP 011213; Note=No experimental confirmation available; Name=4; IsoId=Q86SR1-4; Sequence=VSP 011207, VSP 011208, VSP 011214; Note=No experimental confir |
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Subcellular localization |
Golgi apparatus membrane;Single-pass type II membrane protein(By similarity). |
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Gene name |
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10) |
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Protein sequence
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MRRKEKRLLQAVALVLAALVLLPNVGLWALYRERQPDGTP GGSGAAVAPAAGQGSHSRQKKTFFLGDGQKLKDWHDKEA IRRDAQRVGNGEQGRPYPMTDAERVDQAYRENGFNIYVS DKISLNRSLPDIRHPNCNSKRYLETLPNTSIIIPFHNEG WSSLLRTVHSVLNRSPPELVAEIVLVDDFSDREHLKKPL EDYMALFPSVRILRTKKREGLIRTRMLGASVATGDVITF LDSHCEANVNWLPPLLDRIARNRKTIVCPMIDVIDHDDF RYETQAGDAMRGAFDWEMYYKRIPIPPELQKADPSDPFE SPVMAGGLFAVDRKWFWELGGYDPGLEIWGGEQYEISFK VWMCGGRMEDIPCSRVGHIYRKYVPYKVPAGVSLARNLK RVAEVWMDEYAEYIYQRRPEYRHLSAGDVAVQKKLRSSL NCKSFKWFMTKIAWDLPKFYPPVEPPAAAWGEIRNVGTG LCADTKHGALGSPLRLEGCVRGRGEAAWNNMQVFTFTWR EDIRPGDPQHTKKFCFDAISHTSPVTLYDCHSMKGNQLW KYRKDKTLYHPVSGSCMDCSESDHRIFMNTCNPSSLTQQ WLFEHTNSTVLEKFNRN |
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Database cross reference |
RefSeq Protein accession:NP_938080
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Liver relevance
|
HLPP validation |
Yes/No |
Yes |
|
Project name |
Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0000139;C:Golgi membrane;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. |
|
GO-F |
GO:0046872;F:metal ion binding;IEA:UniProtKB-KW. GO:0004653;F:polypeptide N-acetylgalactosaminyltransferase activity;IEA:EC. GO:0005529;F:sugar binding;IEA:UniProtKB-KW. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr24050 |
PHOSPHORYLATION |
276 |
Y |
PhosphoSitePlus |
LTP |
N |
 
|
|
|
HuLPr24050 |
PHOSPHORYLATION |
293 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr24050 |
PHOSPHORYLATION |
294 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr24050 |
PHOSPHORYLATION |
474 |
T |
PhosphoSitePlus |
LTP |
N |
|
Pathway
| Pathway name |
