HuLPr24099

Uniprot ID

GNAS1_HUMAN

Uniprot Acc

Q5JWF2;A2A2S3;E1P5G3;O75684;O75685;Q5JW67;Q5JWF1;Q9NY42;

Protein name

Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas

Comment

FUNCTION:Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase:it activates the cyclase in response to beta-adrenergic stimuli. XLas isoforms interact with the same set of receptors as Gnas isoforms (By similarity).||SUBUNIT:G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts through its N-terminal region with ALEX which is produced from the same locus in a different open reading frame. This interaction may inhibit its adenylyl cyclase-stimulating activity (By similarity).||SUBCELLULAR LOCATION:Cell membrane; Peripheral membrane protein (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=7; Name=XLas-1; IsoId=Q5JWF2-1; Sequence=Displayed; Note=Gene prediction confirmed by EST data; Name=XLas-2; IsoId=Q5JWF2-2; Sequence=VS

Subcellular localization

Cell membrane;Peripheral membrane protein(By similarity).

Gene name

GNAS complex locus

Protein sequence

MGVRNCLYGNNMSGQRDIPPEIGEQPEQPPLEAPGAAAPG AGPSPAEEMETEPPHNEPIPVENDGEACGPPEVSRPNFQ VLNPAFREAGAHGSYSPPPEEAMPFEAEQPSLGGFWPTL EQPGFPSGVHAGLEAFGPALMEPGAFSGARPGLGGYSPP PEEAMPFEFDQPAQRGCSQLLLQVPDLAPGGPGAAGVPG APPEEPQALRPAKAGSRGGYSPPPEETMPFELDGEGFGD DSPPPGLSRVIAQVDGSSQFAAVAASSAVRLTPAANAPP LWVPGAIGSPSQEAVRPPSNFTGSSPWMEISGPPFEIGS APAGVDDTPVNMDSPPIALDGPPIKVSGAPDKRERAERP PVEEEAAEMEGAADAAEGGKVPSPGYGSPAAGAASADTA ARAAPAAPADPDSGATPEDPDSGTAPADPDSGAFAADPD SGAAPAAPADPDSGAAPDAPADPDSGAAPDAPADPDAGA APEAPAAPAAAETRAAHVAPAAPDAGAPTAPAASATRAA QVRRAASAAPASGARRKIHLRPPSPEIQAADPPTPRPTR ASAWRGKSESSRGRRVYYDEGVASSDDDSSGDESDDGTS GCLRWFQHRRNRRRRKPQRNLLRNFLVQAFGGCFGRSES PQPKASRSLKVKKVPLAEKRRQMRKEALEKRAQKRAEKK RSKLIDKQLQDEKMGYMCTHRLLLLGAGESGKSTIVKQM RILHVNGFNGEGGEEDPQAARSNSDGEKATKVQDIKNNL KEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVP DFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQY FLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDK VNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNM VIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQ DLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPR VTRAKYFIRDEFLRISTASGDGRH

Database cross reference

RefSeq Protein accession:NP_000507
RefSeq Protein gi:4504047

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Fetal Liver;

GO:0005834;C:heterotrimeric G-protein complex;ISS:RefGenome.

GO-F

GO:0031683;F:G-protein beta/gamma-subunit complex binding;ISS:RefGenome. GO:0005525;F:GTP binding;IEA:UniProtKB-KW. GO:0003924;F:GTPase activity;ISS:RefGenome. GO:0035255;F:ionotropic glutamate receptor binding;ISS:RefGenome. GO:0031852;F:mu-type opioi

GO-P

GO:0007191;P:activation of adenylate cyclase activity by dopamine receptor signaling pathway;ISS:RefGenome. GO:0007606;P:sensory perception of chemical stimulus;ISS:RefGenome.

FSH