HuLPr24123

Uniprot ID

GNT2C_HUMAN

Uniprot Acc

Q8NFS9;Q5T4J1;Q6T5E5;

Protein name

N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform C

Comment

FUNCTION:Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells. The expression of the blood group I antigen in erythrocytes is determined by isoform C.||CATALYTIC ACTIVITY:UDP-N-acetyl-D-glucosamine + beta-D- galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D- glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R.||PATHWAY:Protein modification; protein glycosylation.||SUBCELLULAR LOCATION:Golgi apparatus membrane; Single-pass type II membrane protein (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Comment=Isoforms A, B and C have different exons 1, but identical exons 2 and 3; Name=C; Synonyms=IGNTC, IGNT3; IsoId=Q8NFS9-1; Sequence=Displayed; Note=Expressed in reticulocytes. This isoform determines the expression of the blood group I antige

Subcellular localization

Golgi apparatus membrane;Single-pass type II membrane protein(By similarity).

Gene name

glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)

Protein sequence

MNFWRYCFFAFTLLSVVIFVRFYSSQLSPPKSYEKLNSSS ERYFRKTACNHALEKMPVFLWENILPSPLRSVPCKDYLT QNHYITSPLSEEEAAFPLAYVMVIHKDFDTFERLFRAIY MPQNVYCVHVDEKAPAEYKESVRQLLSCFQNAFIASKTE SVVYAGISRLQADLNCLKDLVASEVPWKYVINTCGQDFP LKTNREIVQHLKGFKGKNITPGVLPPDHAIKRTKYVHQE HTDKGGFFVKNTNILKTSPPHQLTIYFGTAYVALTRDFV DFVLRDQRAIDLLQWSKDTYSPDEHFWVTLNRVSGVPGS MPNASWTGNLRAIKWSDMEDRHGGCHGHYVHGICIYGNG DLKWLVNSPSLFANKFELNTYPLTVECLELRHRERTLNQ SETAIQPSWYF

Database cross reference

RefSeq Protein accession:NP_001482
RefSeq Protein gi:4503963

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

GO:0000139;C:Golgi membrane;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW.

GO-F

GO:0008109;F:N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity;IEA:EC.