HuLPr24140

Uniprot ID

GOLI4_HUMAN

Uniprot Acc

O00461;

Protein name

Golgi integral membrane protein 4

Comment

FUNCTION:Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi.||SUBCELLULAR LOCATION:Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Endosome membrane; Single- pass type II membrane protein. Note=Localizes to cis and medial Golgi cisternae. Probably cycles between early Golgi and distal compartments like endosome.||PTM:Phosphorylated probably by c-AMP-dependent kinases in its lumenal part.||PTM:O-glycosylated; modified by sialic acid residues (By similarity).||PTM:N-glycosylated; N-glycans are probably of the complex type and modified by sialic acid residues.||SIMILARITY:Belongs to the GOLIM4 family.

Subcellular localization

Golgi apparatus, Golgi stack membrane;Single-pass type II membrane protein.Endosome membrane;Single- pass type II membrane protein.

Gene name

golgi integral membrane protein 4

Protein sequence

MGNGMCSRKQKRIFQTLLLLTVVFGFLYGAMLYYELQTQL RKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKER LEHKKAKEDFLVYKLEAQETLNKGRQDSNSRYSALNVQH QMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHKQKY LQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQL QDVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYK QLKDTLNRIPSLRKPDPAEQQNVTQVAHSPQGYNTAREK PTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAE FQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVG QAEHLEEEHDPSPEEQDREWKEQHEQREAANLLEGHARA EVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREH QEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELEEG RPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYER DNQHQDEAEGDPGNRHEPREQGPREADPESEADRAAVED INPADDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQK QENTEVEEHLVMAGNPDQQEDNVDEQYQEEAEEEVQEDL TEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDDN RPKGREEHYEEEEEEEEDGAAVAEKSHRRAEM

Database cross reference

RefSeq Protein accession:NP_055313
RefSeq Protein gi:7657138

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0005801;C:cis-Golgi network;TAS:ProtInc. GO:0030139;C:endocytic vesicle;TAS:ProtInc. GO:0010008;C:endosome membrane;IEA:UniProtKB-SubCell. GO:0032580;C:Golgi cisterna membrane;IEA:UniProtKB-SubCell. GO:0005796;C:Golgi lumen;TAS:ProtInc. GO:0016021;

GO-P

GO:0006810;P:transport;IEA:UniProtKB-KW.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr24140

PHOSPHORYLATION

394

Y

Phospho-ELM

11922

HTP

N

HuLPr24140

PHOSPHORYLATION

396

S

Phospho-ELM

11923

HTP

N

HuLPr24140

PHOSPHORYLATION

396

S

PhosphoSitePlus

470157

LTP

N

HuLPr24140

PHOSPHORYLATION

394

Y

PhosphoSitePlus

470158

LTP

HTP

N

HuLPr24140

PHOSPHORYLATION

673

Y

PhosphoSitePlus

458410

LTP

N

TGF_beta_Receptor