Protein basic information
| LiverAtlas Protein ID |
HuLPr24167 |
|
Uniprot ID |
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Uniprot Acc |
Q96PE1;A6H8W3;D3DSW4;Q8N3R1;Q8TEM3;Q96KB2;Q9P1Z7;Q9UFY4; |
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Protein name |
G-protein coupled receptor 124 |
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Comment |
FUNCTION:Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube (By similarity).||SUBUNIT:Interacts with DLG1.||SUBCELLULAR LOCATION:Cell membrane; Multi-pass membrane protein.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q96PE1-1; Sequence=Displayed; Name=2; IsoId=Q96PE1-2; Sequence=VSP 010076; Name=3; IsoId=Q96PE1-3; Sequence=VSP 036215; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Expressed in endothelial cells (at protein level). Abundantly expressed in tumor vessels, heart, placenta, ovary, small intestine, and colon.||DOMAIN:Binds to DLG1 through its PDZ-binding motif.||SIMILARITY:Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.||SIMILARITY:Contains 1 GPS domain.||SIMILARITY:Contains 1 Ig-like (immunoglobulin-like) domain.||SIMILARITY:Contains 4 LRR (leucine-rich) repeats.||SIMILA |
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Subcellular localization |
Cell membrane;Multi-pass membrane protein. |
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Gene name |
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Protein sequence
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MGAGGRRMRGAPARLLLPLLPWLLLLLAPEARGAPGCPLS IRSCKCSGERPKGLSGGVPGPARRRVVCSGGDLPEPPEP GLLPNGTVTLLLSNNKITGLRNGSFLGLSLLEKLDLRNN IISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPR LLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDC HLRWLLPWAQNRSLQLSEHTLCAYPSALHAQALGSLQEA QLCCEGALELHTHHLIPSLRQVVFQGDRLPFQCSASYLG NDTRIRWYHNRAPVEGDEQAGILLAESLIHDCTFITSEL TLSHIGVWASGEWECTVSMAQGNASKKVEIVVLETSASY CPAERVANNRGDFRWPRTLAGITAYQSCLQYPFTSVPLG GGAPGTRASRRCDRAGRWEPGDYSHCLYTNDITRVLYTF VLMPINASNALTLAHQLRVYTAEAASFSDMMDVVYVAQM IQKFLGYVDQIKELVEVMVDMASNLMLVDEHLLWLAQRE DKACSRIVGALERIGGAALSPHAQHISVNARNVALEAYL IKPHSYVGLTCTAFQRREGGVPGTRPGSPGQNPPPEPEP PADQQLRFRCTTGRPNVSLSSFHIKNSVALASIQLPPSL FSSLPAALAPPVPPDCTLQLLVFRNGRLFHSHSNTSRPG AAGPGKRRGVATPVIFAGTSGCGVGNLTEPVAVSLRHWA EGAEPVAAWWSQEGPGEAGGWTSEGCQLRSSQPNVSALH CQHLGNVAVLMELSAFPREVGGAGAGLHPVVYPCTALLL LCLFATIITYILNHSSIRVSRKGWHMLLNLCFHIAMTSA VFAGGITLTNYQMVCQAVGITLHYSSLSTLLWMGVKARV LHKELTWRAPPPQEGDPALPTPSPMLRFYLIAGGIPLII CGITAAVNIHNYRDHSPYCWLVWRPSLGAFYIPVALILL ITWIYFLCAGLRLRGPLAQNPKAGNSRASLEAGEELRGS TRLRGSGPLLSDSGSLLATGSARV |
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Database cross reference |
RefSeq Protein accession:NP_116166
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0016021;C:integral to membrane;TAS:GDB. GO:0005886;C:plasma membrane;IEA:UniProtKB-SubCell. |
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GO-F |
GO:0004930;F:G-protein coupled receptor activity;TAS:GDB. |
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GO-P |
GO:0007417;P:central nervous system development;ISS:UniProtKB. GO:0043542;P:endothelial cell migration;ISS:UniProtKB. GO:0007218;P:neuropeptide signaling pathway;IEA:InterPro. GO:0045765;P:regulation of angiogenesis;ISS:UniProtKB. GO:0050920;P:regulati |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr24167 |
PHOSPHORYLATION |
370 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr24167 |
PHOSPHORYLATION |
377 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr24167 |
PHOSPHORYLATION |
379 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr24167 |
PHOSPHORYLATION |
253 |
S |
PhosphoSitePlus |
HTP |
N |
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Pathway
| Pathway name |
