Protein basic information
| LiverAtlas Protein ID |
HuLPr24205 |
|
Uniprot ID |
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|
Uniprot Acc |
Q53EU6;Q68CJ4;Q6GPI6;Q96NA3; |
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Protein name |
Glycerol-3-phosphate acyltransferase 3 |
|
Comment |
FUNCTION:Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Overexpression activates the mTOR pathway.||CATALYTIC ACTIVITY:Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1- acyl-sn-glycerol 3-phosphate.||ENZYME REGULATION:Inhibited by N-ethylmaleimide (NEM).||PATHWAY:Glycerolipid metabolism; triacylglycerol biosynthesis.||PATHWAY:Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate:step 1/3.||SUBCELLULAR LOCATION:Endoplasmic reticulum membrane; Multi-pass membrane protein.||TISSUE SPECIFICITY:Widely expressed. Expressed in liver, kidney, testis, brain, heart, skeletal muscle, thyroid, prostate, thymus and placenta. Also expressed lung and adipose tissue.||DOMAIN:The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity).||SIMILARITY:Belongs to the 1-acyl-sn |
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Subcellular localization |
Endoplasmic reticulum membrane;Multi-pass membrane protein. |
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Gene name |
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Protein sequence
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MEGAELAGKILSTWLTLVLGFILLPSVFGVSLGISEIYMK ILVKTLEWATIRIEKGTPKESILKNSASVGIIQRDESPM EKGLSGLRGRDFELSDVFYFSKKGLEAIVEDEVTQRFSS EELVSWNLLTRTNVNFQYISLRLTMVWVLGVIVRYCVLL PLRVTLAFIGISLLVIGTTLVGQLPDSSLKNWLSELVHL TCCRICVRALSGTIHYHNKQYRPQKGGICVANHTSPIDV LILTTDGCYAMVGQVHGGLMGIIQRAMVKACPHVWFERS EMKDRHLVTKRLKEHIADKKKLPILIFPEGTCINNTSVM MFKKGSFEIGGTIHPVAIKYNPQFGDAFWNSSKYNMVSY LLRMMTSWAIVCDVWYMPPMTREEGEDAVQFANRVKSAI AIQGGLTELPWDGGLKRAKVKDIFKEEQQKNYSKMIVGNGSLS |
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Database cross reference |
RefSeq Protein accession:NP_116106
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Fetal Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005789;C:endoplasmic reticulum membrane;IDA:UniProtKB. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. |
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GO-F |
GO:0004366;F:glycerol-3-phosphate O-acyltransferase activity;IDA:UniProtKB. |
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GO-P |
GO:0008654;P:phospholipid biosynthetic process;IEA:UniProtKB-KW. GO:0032006;P:regulation of TOR signaling cascade;IDA:UniProtKB. GO:0019432;P:triglyceride biosynthetic process;IDA:UniProtKB. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr24205 |
PHOSPHORYLATION |
68 |
S |
Phospho-ELM |
HTP |
N |
 
|
|
|
HuLPr24205 |
PHOSPHORYLATION |
77 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr24205 |
PHOSPHORYLATION |
66 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr24205 |
PHOSPHORYLATION |
68 |
S |
PhosphoSitePlus |
LTP HTP |
N |
|
|
|
HuLPr24205 |
PHOSPHORYLATION |
77 |
S |
PhosphoSitePlus |
LTP |
N |
|
