Protein basic information
| LiverAtlas Protein ID |
HuLPr24258 |
|
Uniprot ID |
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|
Uniprot Acc |
Q9Y653;A6NIT7;A6NJV9;B0M0K4;O95966;Q8NGB3;Q96HB4; |
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Protein name |
G-protein coupled receptor 56 |
|
Comment |
FUNCTION:Could be involved in cell-cell interactions.||SUBCELLULAR LOCATION:Cell membrane; Multi-pass membrane protein.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y653-1; Sequence=Displayed; Name=2; IsoId=Q9Y653-2; Sequence=VSP 035068;||TISSUE SPECIFICITY:Widely distributed with highest levels found in thyroid gland, brain and heart. Expressed in a great number of tumor cells.||DISEASE:Defects in GPR56 are the cause of bilateral frontoparietal polymicrogyria (BFPP) [MIM:606854]. BFPP is characterized by disorganized cortical lamination that is most severe in frontal cortex.||SIMILARITY:Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.||SIMILARITY:Contains 1 GPS domain.||WEB RESOURCE:Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/GPR56"; |
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Subcellular localization |
Cell membrane;Multi-pass membrane protein. |
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Gene name |
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Protein sequence
|
MTPQSLLQTTLFLLSLLFLVQGAHGRGHREDFRFCSQRNQ THRSSLHYKPTPDLRISIENSEEALTVHAPFPAAHPASR SFPDPRGLYHFCLYWNRHAGRLHLLYGKRDFLLSDKASS LLCFQHQEESLAQGPPLLATSVTSWWSPQNISLPSAASF TFSFHSPPHTAAHNASVDMCELKRDLQLLSQFLKHPQKA SRRPSAAPASQQLQSLESKLTSVRFMGDMVSFEEDRINA TVWKLQPTAGLQDLHIHSRQEEEQSEIMEYSVLLPRTLF QRTKGRSGEAEKRLLLVDFSSQALFQDKNSSQVLGEKVL GIVVQNTKVANLTEPVVLTFQHQLQPKNVTLQCVFWVED PTLSSPGHWSSAGCETVRRETQTSCFCNHLTYFAVLMVS SVEVDAVHKHYLSLLSYVGCVVSALACLVTIAAYLCSRV PLPCRRKPRDYTIKVHMNLLLAVFLLDTSFLLSEPVALT GSEAGCRASAIFLHFSLLTCLSWMGLEGYNLYRLVVEVF GTYVPGYLLKLSAMGWGFPIFLVTLVALVDVDNYGPIIL AVHRTPEGVIYPSMCWIRDSLVSYITNLGLFSLVFLFNM AMLATMVVQILRLRPHTQKWSHVLTLLGLSLVLGLPWAL IFFSFASGTFQLVVLYLFSIITSFQGFLIFIWYWSMRLQ ARGGPSPLKSNSDSARLPISSGSTSSSRI |
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Database cross reference |
RefSeq Protein accession:NP_001139242
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005887;C:integral to plasma membrane;TAS:ProtInc. |
|
GO-F |
GO:0004930;F:G-protein coupled receptor activity;TAS:GDB. |
|
GO-P |
GO:0007420;P:brain development;IMP:GDB. GO:0007155;P:cell adhesion;IDA:GDB. GO:0007267;P:cell-cell signaling;TAS:ProtInc. GO:0007218;P:neuropeptide signaling pathway;IEA:InterPro. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr24258 |
PHOSPHORYLATION |
689 |
S |
Phospho-ELM |
HTP |
N |
 
|
|
|
HuLPr24258 |
PHOSPHORYLATION |
690 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr24258 |
PHOSPHORYLATION |
691 |
S |
Phospho-ELM |
HTP |
N |
|
Pathway
| Pathway name |
