Protein basic information
| LiverAtlas Protein ID |
HuLPr24299 |
|
Uniprot ID |
|
|
Uniprot Acc |
Q6IC98;A9IN51;A9IN57;Q68EN0;Q9UGE6;Q9Y4B9; |
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Protein name |
GRAM domain-containing protein 4 |
|
Comment |
FUNCTION:Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53.||SUBCELLULAR LOCATION:Mitochondrion membrane; Multi-pass membrane protein (Potential). Note=Colocalizes with COX4I1.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6IC98-1; Sequence=Displayed; Name=2; IsoId=Q6IC98-2; Sequence=VSP 032771; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Expressed in lung and in primary lung squamous cell carcinoma (LSCC).||INDUCTION:Up-regulated in the mitochondria by E2F1 after addition of 4-hydroxytamoxifen (at protein level).||SIMILARITY:Contains 1 GRAM domain.||SEQUENCE CAUTION:Sequence=BAA34487.2; Type=Erroneous initiation; |
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Subcellular localization |
Mitochondrion membrane;Multi-pass membrane protein(Potential). |
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Gene name |
|
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Protein sequence
|
MLRRLDKIRFRGHKRDDFLDLAESPNASDTECSDEIPLKV PRTSPRDSEELRDPAGPGTLIMATGVQDFNRTEFDRLNE IKGHLEIALLEKHFLQEELRKLREETNAEMLRQELDRER QRRMELEQKVQEVLKARTEEQMAQQPPKGQAQASNGAER RSQGLSSRLQKWFYERFGEYVEDFRFQPEENTVETEEPL SARRLTENMRRLKRGAKPVTNFVKNLSALSDWYSVYTSA IAFTVYMNAVWHGWAIPLFLFLAILRLSLNYLIARGWRI QWSIVPEVSEPVEPPKEDLTVSEKFQLVLDVAQKAQNLF GKMADILEKIKNLFMWVQPEITQKLYVALWAAFLASCFF PYRLVGLAVGLYAGIKFFLIDFIFKRCPRLRAKYDTPYI IWRSLPTDPQLKERSSAAVSRRLQTTSSRSYVPSAPAGL GKEEDAGRFHSTKKGNFHEIFNLTENERPLAVCENGWRC CLINRDRKMPTDYIRNGVLYVTENYLCFESSKSGSSKRN KVIKLVDITDIQKYKVLSVLPGSGMGIAVSTPSTQKPLV FGAMVHRDEAFETILSQYIKITSAAASGGDS |
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Database cross reference |
RefSeq Protein accession:NP_055939
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
French Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0031966;C:mitochondrial membrane;IEA:UniProtKB-SubCell. |
|
GO-P |
GO:0006915;P:apoptosis;IEA:UniProtKB-KW. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr24299 |
PHOSPHORYLATION |
24 |
S |
PhosphoSitePlus |
LTP |
N |
 
|
|
|
HuLPr24299 |
PHOSPHORYLATION |
28 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr24299 |
PHOSPHORYLATION |
30 |
T |
PhosphoSitePlus |
LTP |
N |
|
Pathway
| Pathway name | |
| Pathway name | |
| Pathway name |
