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Protein basic information

LiverAtlas Protein ID

HuLPr24343

Uniprot ID

GRL1A_HUMAN

Uniprot Acc

P0CAP2;Q6EER8;Q6EES2;Q6EEV3;Q6EF00;Q6EF01;Q6EF02;Q6EF46;Q6EFN8;Q6EM48;Q6K046;Q6K050;Q6K051;Q6ZQZ3;Q8NC58;Q8NCF3;Q96DI5;Q96JB7;Q96NF5;Q9Y3V6;

Protein name

Protein GRINL1A

Comment

FUNCTION:Isoform 1 appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. Isoform 1 may play a role in the Mediator complex-dependent regulation of transcription activation. Isoform 1 acts in vitro as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II.||SUBUNIT:Isoform 1 is a component of the Pol II(G) complex, which contains the RNA polymerase II (Pol II) core complex subunits and GRINL1A isoform 1. Pol II(G) appears to be an abundant form of Pol II.||SUBCELLULAR LOCATION:Isoform 1:Nucleus (Probable).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=6; Comment=Additional isoforms seem to exist; Name=1; Synonyms=Gdown1; IsoI

Subcellular localization

Isoform 1:Nucleus(Probable).

Gene name

glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A

Protein sequence

MCSLPRGFEPQAPEDLAQRSLVELREMLKRQERLLRNEKF ICKLPDKGKKIFDSFAKLKAAIAECEEVRRKSELFNPVS LDCKLRQKAIAEVDVGTDKAQNSDPILDTSSLVPGCSSV DNIKSSQTSQNQGLGRPTLEGDEETSEVEYTVNKGPASS NRDRVPPSSEASEHHPRHRVSSQAEDTSSSFDNLFIDRL QRITIADQGEQQSEENASTKNLTGLSSGTEKKPHYMEVL EMRAKNPVPQLRKFKTNVLPFRQNDSSSHCQKSGSPISS EERRRRDKQHLDDITAARLLPLHHMPTQLLSIEESLALQ KQQKQNYEEMQAKLAAQKLAERLNIKMRSYNPEGESSGR YREVRDEDDDWSSDEF

Database cross reference

RefSeq Protein accession:NP_001018112
RefSeq Protein gi:70166832

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005635;C:nuclear envelope;IDA:LIFEdb.

GO-F

GO:0003899;F:DNA-directed RNA polymerase activity;IEA:UniProtKB-KW.

Pathway

Pathway name

IL2