Protein basic information
| LiverAtlas Protein ID |
HuLPr24365 |
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Uniprot ID |
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Uniprot Acc |
P11021;B0QZ61;Q2EF78;Q9NPF1;Q9UK02; |
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Protein name |
78 kDa glucose-regulated protein |
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Comment |
FUNCTION:Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.||SUBUNIT:Interacts with DNAJC1 (via J domain) (By similarity). Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Part a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Interacts with TMEM132A and TRIM21. May form a complex with ERLEC1, OS9, SEL1L and SYVN1.||INTERACTION:Q9NZJ5:EIF2AK3; NbExp=1; IntAct=EBI-354921, EBI-766076; Q92597:NDRG1; NbExp=1; IntAct=EBI-354921, EBI-716486; Q96IZ0:PAWR; NbExp=4; IntAct=EBI-354921, EBI-595869; Q62627:Pawr (xeno); NbExp=2; IntAct=EBI-354921, EBI-1187240; P60484:PTEN; NbExp=1; IntAct=EBI-354921, EBI-696162; P04049:RAF1; NbExp=3; IntAct=EBI-354921, EBI-365996;||SUBCELLULAR LOCATION:Endoplasmic reticulum lumen. Melanosome. Note=Identifie |
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Subcellular localization |
Endoplasmic reticulum lumen.Melanosome. |
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Gene name |
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) |
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Related liver disease name |
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Protein sequence
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MKLSLVAAMLLLLSAARAEEEDKKEDVGTVVGIDLGTTYS CVGVFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDA AKNQLTSNPENTVFDAKRLIGRTWNDPSVQQDIKFLPFK VVEKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETA EAYLGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVM RIINEPTAAAIAYGLDKREGEKNILVFDLGGGTFDVSLL TIDNGVFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKT GKDVRKDNRAVQKLRREVEKAKRALSSQHQARIEIESFY EGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLK KSDIDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPD EAVAYGAAVQAGVLSGDQDTGDLVLLDVCPLTLGIETVG GVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGE RPLTKDNHLLGTFDLTGIPPAPRGVPQIEVTFEIDVNGI LRVTAEDKGTGNKNKITITNDQNRLTPEEIERMVNDAEK FAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKL SSEDKETMEKAVEEKIEWLESHQDADIEDFKAKKKELEE IVQPIISKLYGSAGPPPTGEEDTAEKDEL |
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Database cross reference |
RefSeq Protein accession:NP_005338
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Liver relevance
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HCC significant Proteins |
Yes/No |
Yes |
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Quality score |
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;French Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0009986;C:cell surface;IDA:UniProtKB. GO:0034663;C:endoplasmic reticulum chaperone complex;IDA:UniProtKB. GO:0005788;C:endoplasmic reticulum lumen;TAS:UniProtKB. GO:0005793;C:ER-Golgi intermediate compartment;IDA:UniProtKB. GO:0030176;C:integral to |
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GO-F |
GO:0005524;F:ATP binding;NAS:UniProtKB. GO:0016887;F:ATPase activity;ISS:UniProtKB. GO:0005509;F:calcium ion binding;TAS:UniProtKB. GO:0043027;F:caspase inhibitor activity;IDA:UniProtKB. GO:0051087;F:chaperone binding;TAS:BHF-UCL. GO:0051787;F:misfold |
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GO-P |
GO:0006916;P:anti-apoptosis;IMP:UniProtKB. GO:0042149;P:cellular response to glucose starvation;IDA:UniProtKB. GO:0030433;P:ER-associated protein catabolic process;TAS:BHF-UCL. GO:0043154;P:negative regulation of caspase activity;IDA:UniProtKB. GO |