HuLPr24380

Uniprot ID

GSDMB_HUMAN

Uniprot Acc

Q8TAX9;Q7Z377;Q8WY76;Q9NX71;Q9P163;

Protein name

Gasdermin-B

Comment

FUNCTION:May play a role as secretory or metabolic product involved in secretory pathway. May also play a role in achieving and maintaining the final differentiation state of epithelial cells.||SUBCELLULAR LOCATION:Cytoplasm. Note=Vesicular localization in the apical region of gastric chief cells and colonic surface mucous cells, and the basal region of neuroendocrine cells.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=5; Comment=Isoforms expression varies between tumor and non-tumor cells and changes in the regulation of isoforms transcription and translation may be seen in the development of gastrointestinal and hepatic cancers; Name=1; IsoId=Q8TAX9-1; Sequence=Displayed; Name=2; IsoId=Q8TAX9-2; Sequence=VSP 032937; Name=3; IsoId=Q8TAX9-3; Sequence=VSP 032938; Name=4; IsoId=Q8TAX9-4; Sequence=VSP 032939, VSP 032940; Name=5; IsoId=Q8TAX9-5; Sequence=VSP 032936; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Expressed in gastric

Subcellular localization

Cytoplasm.

Gene name

gasdermin B

Protein sequence

MFSVFEEITRIVVKEMDAGGDMIAVRSLVDADRFRCFHLV GEKRTFFGCRHYTTGLTLMDILDTDGDKWLDELDSGLQG QKAEFQILDNVDSTGELIVRLPKEITISGSFQGFHHQKI KISENRISQQYLATLENRKLKRELPFSFRSINTRENLYL VTETLETVKEETLKSDRQYKFWSQISQGHLSYKHKGQRE VTIPPNRVLSYRVKQLVFPNKETMSAGLDIHFRGKTKSF PEGKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKDVLNS LAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSS LFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALEK GTLPLLKDQVKSVMEQNWDELASSPPDMDYDPEARILCA LYVVVSILLELAEGPTSVSS

Database cross reference

RefSeq Protein accession:NP_001035936
RefSeq Protein gi:109689703

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;

GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell.