HuLPr24503

Uniprot ID

H2B2D_HUMAN

Uniprot Acc

Q6DRA6;

Protein name

Putative histone H2B type 2-D

Comment

FUNCTION:Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.||SUBUNIT:The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.||SUBCELLULAR LOCATION:Nucleus. Chromosome.||PTM:Phosphorylated on Ser-15 by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class- switch recombination.||MISCELLANE

Subcellular localization

Nucleus.Chromosome.

Gene name

histone cluster 2, H2bc

Protein sequence

MPEPAKFAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSI YVYKVLKRVHPDTGIWCKAMGIMNSFLNDIFERIAGEAS RLAHYNKRSTITSRRSRRPCACCCPASWPSTPCPRAPRR SPSTPAPSESLPGPGARSLPPSLPPRVAGCFVSKGSFQG HLTPLVK

Database cross reference

HLPP validation

Yes/No

Yes

Project name

French Liver;Human Liver Organelles;

GO:0000786;C:nucleosome;IEA:UniProtKB-KW. GO:0005634;C:nucleus;IEA:UniProtKB-SubCell.

GO-F

GO:0003677;F:DNA binding;IEA:UniProtKB-KW.

GO-P

GO:0006334;P:nucleosome assembly;IEA:InterPro.