HuLPr24526

Uniprot ID

HACD3_HUMAN

Uniprot Acc

Q9P035;A0PJA1;Q280Z3;Q6PD63;Q8IUI5;Q8NC86;Q8NCB1;Q96T12;Q9NQA7;

Protein name

3-hydroxyacyl-CoA dehydratase 3

Comment

FUNCTION:Responsible for the dehydration step in very long-chain fatty acids (VLCFAs) synthesis. Involved in Rac1-signaling pathways leading to the modulation of gene expression.||SUBUNIT:Interact with the condensation enzymes of the ELOVL family. Interacts with RAC1.||INTERACTION:Q9HAW0:BRF2; NbExp=1; IntAct=EBI-359013, EBI-1055224; Q9BUV8:C20orf24; NbExp=1; IntAct=EBI-359013, EBI-1050079; Q9HC98:NEK6; NbExp=1; IntAct=EBI-359013, EBI-740364; Q9BRX2:PELO; NbExp=1; IntAct=EBI-359013, EBI-1043580; Q13530:SERINC3; NbExp=1; IntAct=EBI-359013, EBI-1045571; Q96FV3:TSPAN17; NbExp=1; IntAct=EBI-359013, EBI-1044605;||SUBCELLULAR LOCATION:Endoplasmic reticulum membrane; Multi-pass membrane protein.||TISSUE SPECIFICITY:Highly expressed in testis, kidney, brain, liver and weakly in skeletal muscle, spleen and heart. No expression detected in leukocytes.||INDUCTION:By AKAP12 and histone deacetylase inhibitors such as sodium butyrate.||SIMILARITY:Belongs to the very long-chain fatty acids dehydratas

Subcellular localization

Endoplasmic reticulum membrane;Multi-pass membrane protein.

Gene name

protein tyrosine phosphatase-like A domain containing 1

Protein sequence

MENQVLTPHVYWAQRHRELYLRVELSDVQNPAISITENVL HFKAQGHGAKGDNVYEFHLEFLDLVKPEPVYKLTQRQVN ITVQKKVSQWWERLTKQEKRPLFLAPDFDRWLDESDAEM ELRAKEEERLNKLRLESEGSPETLTNLRKGYLFMYNLVQ FLGFSWIFVNLTVRFCILGKESFYDTFHTVADMMYFCQM LAVVETINAAIGVTTSPVLPSLIQLLGRNFILFIIFGTM EEMQNKAVVFFVFYLWSAIEIFRYSFYMLTCIDMDWKVL TWLRYTLWIPLYPLGCLAEAVSVIQSIPIFNETGRFSFT LPYPVKIKVRFSFFLQIYLIMIFLGLYINFRHLYKQRRR RYGQKKKKIH

Database cross reference

RefSeq Protein accession:NP_057479
RefSeq Protein gi:117168248

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles;

GO:0005789;C:endoplasmic reticulum membrane;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW.

GO-F

GO:0005096;F:GTPase activator activity;TAS:ProtInc. GO:0016829;F:lyase activity;IEA:UniProtKB-KW. GO:0005515;F:protein binding;IPI:IntAct.

GO-P

GO:0007257;P:activation of JUN kinase activity;TAS:ProtInc. GO:0006633;P:fatty acid biosynthetic process;IEA:UniProtKB-KW. GO:0007249;P:I-kappaB kinase/NF-kappaB cascade;TAS:ProtInc. GO:0016601;P:Rac protein signal transduction;NAS:UniProtKB.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr24526

PHOSPHORYLATION

114

S

PhosphoSitePlus

449171

LTP

yes