Protein basic information
LiverAtlas Protein ID |
HuLPr24552 |
Uniprot ID |
|
Uniprot Acc |
Q8TDQ0;B2RAY2;Q8WW60;Q96K94; |
Protein name |
Hepatitis A virus cellular receptor 2 |
Comment |
FUNCTION:Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9.||SUBCELLULAR LOCATION:Membrane; Single-pass type I membrane protein (Potential).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8TDQ0-1; Sequence=Displayed; Name=2; IsoId=Q8TDQ0-2; Sequence=VSP 017287, VSP 017288;||TISSUE SPECIFICITY:T-helper type 1 lymphocyte (Th1)-specific.||SIMILARITY:Belongs to the immunoglobulin superfamily. TIM family.||SIMILARITY:Contains 1 Ig-like V-type (immunoglobulin-like) domain. |
Subcellular localization |
Membrane;Single-pass type I membrane protein(Potential). |
Gene name |
|
Related liver disease name |
|
Protein sequence
|
MFSHLPFDCVLLLLLLLLTRSSEVEYRAEVGQNAYLPCFY TPAAPGNLVPVCWGKGACPVFECGNVVLRTDERDVNYWT SRYWLNGDFRKGDVSLTIENVTLADSGIYCCRIQIPGIM NDEKFNLKLVIKPAKVTPAPTRQRDFTAAFPRMLTTRGH GPAETQTLGSLPDINLTQISTLANELRDSRLANDLRDSG ATIRIGIYIGAGICAGLALALIFGALIFKWYSHSKEKIQ NLSLISLANLPPSGLANAVAEGIRSEENIYTIEENVYEV EEPNEYYCYVSSRQQPSQPLGCRFAMP |
Database cross reference |
RefSeq Protein accession:NP_116171
|
Liver relevance
HLPP validation |
Yes/No |
Yes |
Project name |
French Liver;Human Fetal Liver;Human Liver Organelles;Chinese Liver; |
Ontology annotation
GO-C |
GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. |
Post-translational modification
LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
HuLPr24552 |
PHOSPHORYLATION |
265 |
Y |
PhosphoSitePlus |
LTP HTP |
N |