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Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr24552

Uniprot ID

HAVR2_HUMAN

Uniprot Acc

Q8TDQ0;B2RAY2;Q8WW60;Q96K94;

Protein name

Hepatitis A virus cellular receptor 2

Comment

FUNCTION:Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9.||SUBCELLULAR LOCATION:Membrane; Single-pass type I membrane protein (Potential).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8TDQ0-1; Sequence=Displayed; Name=2; IsoId=Q8TDQ0-2; Sequence=VSP 017287, VSP 017288;||TISSUE SPECIFICITY:T-helper type 1 lymphocyte (Th1)-specific.||SIMILARITY:Belongs to the immunoglobulin superfamily. TIM family.||SIMILARITY:Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Subcellular localization

Membrane;Single-pass type I membrane protein(Potential).

Gene name

hepatitis A virus cellular receptor 2

Related liver disease name

Hepatitis A

Protein sequence

MFSHLPFDCVLLLLLLLLTRSSEVEYRAEVGQNAYLPCFY TPAAPGNLVPVCWGKGACPVFECGNVVLRTDERDVNYWT SRYWLNGDFRKGDVSLTIENVTLADSGIYCCRIQIPGIM NDEKFNLKLVIKPAKVTPAPTRQRDFTAAFPRMLTTRGH GPAETQTLGSLPDINLTQISTLANELRDSRLANDLRDSG ATIRIGIYIGAGICAGLALALIFGALIFKWYSHSKEKIQ NLSLISLANLPPSGLANAVAEGIRSEENIYTIEENVYEV EEPNEYYCYVSSRQQPSQPLGCRFAMP

Database cross reference

RefSeq Protein accession:NP_116171
RefSeq Protein gi:49574534

Liver relevance

HLPP validation

Yes/No

Yes

Project name

French Liver;Human Fetal Liver;Human Liver Organelles;Chinese Liver;

Ontology annotation

GO-C

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW.

Post-translational modification

LiverAtlas Protein ID

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr24552

PHOSPHORYLATION

265

Y

PhosphoSitePlus

470136

LTP

HTP

N