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Protein basic information

LiverAtlas Protein ID

HuLPr24578

Uniprot ID

HCN3_HUMAN

Uniprot Acc

Q9P1Z3;D3DV90;Q4VX12;Q8N6W6;Q9BWQ2;

Protein name

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3

Comment

FUNCTION:Putative hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions (By similarity).||SUBUNIT:The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits.||SUBCELLULAR LOCATION:Membrane; Multi-pass membrane protein.||DOMAIN:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.||SIMILARITY:Belongs to the potassium channel HCN family.||SIMILARITY:Contains 1 cyclic nucleotide-binding domain.||SEQUENCE CAUTION:Sequence=AAH28024.2; Type=Erroneous initiation;

Subcellular localization

Membrane;Multi-pass membrane protein.

Gene name

hyperpolarization activated cyclic nucleotide-gated potassium channel 3

Protein sequence

MEAEQRPAAGASEGATPGLEAVPPVAPPPATAASGPIPKS GPEPKRRHLGTLLQPTVNKFSLRVFGSHKAVEIEQERVK SAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFF KEENSPPWIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEI LLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVELEPRL DAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWE EIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPM LQDFPPDCWVSINHMVNHSWGRQYSHALFKAMSHMLCIG YGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQS LDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHR YQGKMFDEESILGELSEPLREEIINFTCRGLVAHMPLFA HADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQ HGLLSVLARGARDTRLTDGSYFGEICLLTRGRRTASVRA DTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLLRI GKKNSILQRKRSEPSPGSSGGIMEQHLVQHDRDMARGVR GRAPSTGAQLSGKPVLWEPLVHAPLQAAAVTSNVAIALT HQRGPLPLSPDSPATLLARSAWRSAGSPASPLVPVRAGP WASTSRLPAPPARTLHASLSRAGRSQVSLLGPPPGGGGR RLGPRGRPLSASQPSLPQRATGDGSPGRKGSGSERLPPS GLLAKPPRTAQPPRPPVPEPATPRGLQLSANM

Database cross reference

RefSeq Protein accession:NP_065948
RefSeq Protein gi:38327037

Liver relevance

HLPP validation

Yes/No

Yes

Project name

French Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW.

GO-F

GO:0030552;F:cAMP binding;IEA:UniProtKB-KW. GO:0005272;F:sodium channel activity;IEA:UniProtKB-KW. GO:0005249;F:voltage-gated potassium channel activity;IEA:InterPro.