HuLPr24613

Uniprot ID

HECAM_HUMAN

Uniprot Acc

Q14CZ8;Q67IP8;Q6ZWL4;Q8N7I3;Q8ND35;

Protein name

Hepatocyte cell adhesion molecule

Comment

FUNCTION:Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation.||SUBUNIT:Homodimer. Dimer formation occurs predominantly through cis interactions on the cell surface.||SUBCELLULAR LOCATION:Cytoplasm. Membrane; Single-pass type I membrane protein; Cytoplasmic side. Note=In MCF7 breast carcinoma and hepatic Hep3B and HepG2 cell lines, localization of HEPACAM is cell density-dependent. In well spread cells, localized to punctate structures in the perinuclear membrane, cytoplasm, and at cell surface of protusions. In confluent cells, localized predominantly to the cytoplasmic membrane, particularly in areas of cell-cell contacts. Colocalizes with CDH1.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14CZ8-1; Sequence=Displayed; Name=2; IsoId=Q14CZ8-2; Sequence=VSP 052497, VSP 052498; Note=No experimental confirmation available;||INDUCTION:Down-regulated in 20 out of 23 of

Subcellular localization

Cytoplasm.Membrane;Single-pass type I membrane protein;Cytoplasmic side.

Gene name

hepatic and glial cell adhesion molecule

Protein sequence

MKRERGALSRASRALRLAPFVYLLLIQTDPLEGVNITSPV RLIHGTVGKSALLSVQYSSTSSDRPVVKWQLKRDKPVTV VQSIGTEVIGTLRPDYRDRIRLFENGSLLLSDLQLADEG TYEVEISITDDTFTGEKTINLTVDVPISRPQVLVASTTV LELSEAFTLNCSHENGTKPSYTWLKDGKPLLNDSRMLLS PDQKVLTITRVLMEDDDLYSCMVENPISQGRSLPVKITV YRRSSLYIILSTGGIFLLVTLVTVCACWKPSKRKQKKLE KQNSLEYMDQNDDRLKPEADTLPRSGEQERKNPMALYIL KDKDSPETEENPAPEPRSATEPGPPGYSVSPAVPGRSPG LPIRSARRYPRSPARSPATGRTHSSPPRAPSSPGRSRSA SRTLRTAGVHIIREQDEAGPVEISA

Database cross reference

RefSeq Protein accession:NP_689935
RefSeq Protein gi:121674801

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW.

GO-P

GO:0007155;P:cell adhesion;IEA:UniProtKB-KW. GO:0007050;P:cell cycle arrest;IEA:UniProtKB-KW. GO:0040008;P:regulation of growth;IEA:UniProtKB-KW.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr24613

PHOSPHORYLATION

278

S

PhosphoSitePlus

486040

LTP

N

HuLPr24613

PHOSPHORYLATION

383

S

PhosphoSitePlus

481233

LTP

yes

HuLPr24613

PHOSPHORYLATION

384

S

PhosphoSitePlus

481234

LTP

HTP

yes

HuLPr24613

PHOSPHORYLATION

318

S

PhosphoSitePlus

485866

LTP

yes