HuLPr24656

Uniprot ID

HES5_HUMAN

Uniprot Acc

Q5TA89;B9DI85;

Protein name

Transcription factor HES-5

Comment

FUNCTION:Transcriptional repressor of genes that require a bHLH protein for their transcription (By similarity).||SUBUNIT:Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family (By similarity).||SUBCELLULAR LOCATION:Nucleus (By similarity).||TISSUE SPECIFICITY:Expressed in fetal heart and brain tumors.||DOMAIN:Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG) (By similarity).||DOMAIN:The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins (By similarity).||SIMILARITY:Contains 1 basic helix-loop-helix (bHLH) domain.||SIMILARITY:Contains 1 Orange domain.

Subcellular localization

Nucleus(By similarity).

Gene name

hairy and enhancer of split 5 (Drosophila)

Protein sequence

MAPSTVAVELLSPKEKNRLRKPVVEKMRRDRINSSIEQLK LLLEQEFARHQPNSKLEKADILEMAVSYLKHSKAFVAAA GPKSLHQDYSEGYSWCLQEAVQFLTLHAASDTQMKLLYH FQRPPAAPAAPAKEPKAPGAAPPPALSAKATAAAAAAHQ PACGLWRPW

Database cross reference

RefSeq Protein accession:NP_001010926
RefSeq Protein gi:58219048

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;

GO:0005634;C:nucleus;IEA:UniProtKB-SubCell.

GO-F

GO:0030528;F:transcription regulator activity;IEA:InterPro.

GO-P

GO:0006351;P:transcription, DNA-dependent;IEA:UniProtKB-KW.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr24656

PHOSPHORYLATION

5

T

PhosphoSitePlus

3072111

HTP

N

HuLPr24656

PHOSPHORYLATION

4

S

PhosphoSitePlus

3072131

LTP

N

HuLPr24656

PHOSPHORYLATION

12

S

PhosphoSitePlus

3072403

HTP

N

CDC42_signaling_events

Notch_signaling_pathway