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Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr24666

Uniprot ID

HEY2_HUMAN

Uniprot Acc

Q9UBP5;

Protein name

Hairy/enhancer-of-split related with YRPW motif protein 2

Comment

FUNCTION:Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'- CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.||SUBUNIT:May self-associate (By similarity). Interacts with GATA4, HES1 and HEYL (By similarity). Interacts with HDAC1, NCOR1 and SIN3A (By similarity). Interacts with ARNT and GATA6.||SUBCELLULAR LOCATION:Nucleus (By similarity).||SIMILARITY:Belongs to the HEY family.||SIMILARITY:Contains 1 basic helix-loop-helix (bHLH) domain.||SIMILARITY:Contains 1 Orange domain.

Subcellular localization

Nucleus(By similarity).

Gene name

hairy/enhancer-of-split related with YRPW motif 2

Protein sequence

MKRPCEETTSESDMDETIDVGSENNYSGQSTSSVIRLNSP TTTSQIMARKKRRGIIEKRRRDRINNSLSELRRLVPTAF EKQGSAKLEKAEILQMTVDHLKMLQATGGKGYFDAHALA MDFMSIGFRECLTEVARYLSSVEGLDSSDPLRVRLVSHL STCATQREAAAMTSSMAHHHHPLHPHHWAAAFHHLPAAL LQPNGLHASESTPCRLSTTSEVPPAHGSALLTATFAHAD SALRMPSTGSVAPCVPPLSTSLLSLSATVHAAAAAATAA AHSFPLSFAGAFPMLPPNAAAAVAAATAISPPLSVSATS SPQQTSSGTNNKPYRPWGTEVGAF

Database cross reference

RefSeq Protein accession:NP_036391
RefSeq Protein gi:6912414

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005634;C:nucleus;IEA:UniProtKB-SubCell.

GO-F

GO:0003677;F:DNA binding;TAS:ProtInc. GO:0042826;F:histone deacetylase binding;IPI:BHF-UCL. GO:0003700;F:sequence-specific DNA binding transcription factor activity;TAS:ProtInc. GO:0016564;F:transcription repressor activity;IDA:BHF-UCL.

GO-P

GO:0010553;P:negative regulation of gene-specific transcription from RNA polymerase II promoter;IDA:BHF-UCL. GO:0007399;P:nervous system development;TAS:ProtInc. GO:0007219;P:Notch signaling pathway;IEA:UniProtKB-KW. GO:0009887;P:organ morphogenesis;TAS

Pathway

Pathway name

Notch-mediated_HES/HEY_network

Pathway name

p73_transcription_factor_network

Pathway name

Notch_signaling_pathway