HuLPr24667

Uniprot ID

HEYL_HUMAN

Uniprot Acc

Q9NQ87;Q5TG99;

Protein name

Hairy/enhancer-of-split related with YRPW motif-like protein

Comment

FUNCTION:Downstream effector of Notch signaling which may be required for cardiovascular development (By similarity). Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity). Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.||SUBUNIT:Self-associates (By similarity). Interacts with GATA4, GATA6, HES1, HEY1 and HEY2 (By similarity). Interacts with HDAC1, NCOR1 and SIN3A (By similarity).||SUBCELLULAR LOCATION:Nucleus (By similarity).||INDUCTION:By activation of the Notch signaling pathway.||SIMILARITY:Belongs to the HEY family.||SIMILARITY:Contains 1 basic helix-loop-helix (bHLH) domain.||SIMILARITY:Contains 1 Orange domain.

Subcellular localization

Nucleus(By similarity).

Gene name

hairy/enhancer-of-split related with YRPW motif-like

Protein sequence

MKRPKEPSGSDGESDGPIDVGQEGQLSQMARPLSTPSSSQ MQARKKHRGIIEKRRRDRINSSLSELRRLVPTAFEKQGS SKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFRS IGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYA AEMEPSPTPTGPLAFPAWPWSFFHSCPGLPALSNQLAIL GRVPSPVLPGVSSPAYPIPALRTAPLRRATGIILPARRN VLPSRGASSTRRARPLERPATPVPVAPSSRAARSSHIAP LLQSSSPTPPGPTGSAAYVAVPTPNSSSPGPAGRPAGAM LYHSWVSEITEIGAF

Database cross reference

RefSeq Protein accession:NP_055386
RefSeq Protein gi:7657154

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles;

GO:0005634;C:nucleus;IEA:UniProtKB-SubCell.

GO-F

GO:0003677;F:DNA binding;IEA:UniProtKB-KW. GO:0003700;F:sequence-specific DNA binding transcription factor activity;NAS:ProtInc. GO:0030528;F:transcription regulator activity;IEA:InterPro.

GO-P

GO:0007399;P:nervous system development;TAS:ProtInc. GO:0007219;P:Notch signaling pathway;IEA:UniProtKB-KW. GO:0006355;P:regulation of transcription, DNA-dependent;IEA:UniProtKB-KW.

Notch_signaling_pathway

TGF_beta_Receptor