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Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr24723

Uniprot ID

HLX_HUMAN

Uniprot Acc

Q14774;B2R8A8;Q15988;Q59HE7;Q9NZ75;

Protein name

H2.0-like homeobox protein

Comment

FUNCTION:Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis (By similarity).||SUBCELLULAR LOCATION:Nucleus (Potential).||TISSUE SPECIFICITY:Low level in normal B and T-cells, high level in activated lymphocytes and monocytes. Also found in thymus, tonsil, bone marrow, developing vessels, and fetal brain.||SIMILARITY:Belongs to the H2.0 homeobox family.||SIMILARITY:Contains 1 homeobox DNA-binding domain.||SEQUENCE CAUTION:Sequence=BAD92049.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAD92049.1; Type=Frameshift; Positions=198, 259, 321; Sequence=M60721; Type=Frameshift; Positions=69, 115, 152, 167;

Subcellular localization

Nucleus(Potential).

Gene name

H2.0-like homeobox

Protein sequence

MFAAGLAPFYASNFSLWSAAYCSSAGPGGCSFPLDPAAVK KPSFCIADILHAGVGDLGAAPEGLAGASAAALTAHLGSV HPHASFQAAARSPLRPTPVVAPSEVPAGFPQRLSPLSAA YHHHHPQQQQQQQQPQQQQPPPPPRAGALQPPASGTRVV PNPHHSGSAPAPSSKDLKFGIDRILSAEFDPKVKEGNTL RDLTSLLTGGRPAGVHLSGLQPSAGQFFASLDPINEASA ILSPLNSNPRNSVQHQFQDTFPGPYAVLTKDTMPQTYKR KRSWSRAVFSNLQRKGLEKRFEIQKYVTKPDRKQLAAML GLTDAQVKVWFQNRRMKWRHSKEAQAQKDKDKEAGEKPS GGAPAADGEQDERSPSRSEGEAESESSDSESLDMAPSDT ERTEGSERSLHQTTVIKAPVTGALITASSAGSGGSSGGG GNSFSFSSASSLSSSSTSAGCASSLGGGGASELLPATQP TASSAPKSPEPAQGALGCL

Database cross reference

RefSeq Protein accession:NP_068777
RefSeq Protein gi:11386181

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005634;C:nucleus;IEA:UniProtKB-SubCell.

GO-F

GO:0043565;F:sequence-specific DNA binding;IDA:MGI. GO:0003700;F:sequence-specific DNA binding transcription factor activity;IEA:InterPro. GO:0030528;F:transcription regulator activity;IEA:InterPro.

GO-P

GO:0030154;P:cell differentiation;IEA:UniProtKB-KW. GO:0006355;P:regulation of transcription, DNA-dependent;IEA:UniProtKB-KW.

Pathway

Pathway name

IL12-mediated_signaling_events

Pathway name

IL5