Protein basic information
| LiverAtlas Protein ID |
HuLPr24820 |
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Uniprot ID |
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Uniprot Acc |
P00738;B0AZL5;P00737;Q0VAC4;Q2PP15;Q3B7J0;Q6LBY9;Q9UC67; |
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Protein name |
Haptoglobin |
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Comment |
FUNCTION:Haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes.||SUBUNIT:Tetramer of two alpha and two beta chains.||SUBCELLULAR LOCATION:Secreted.||TISSUE SPECIFICITY:Expressed by the liver and secreted in plasma.||POLYMORPHISM:In the human populations there are two major allelic forms, alpha-1 with 83 residues and alpha-2 with 142 residues. These alleles determine the 3 major phenotypes HP*1F/HP*1S and HP*2FS. The two main alleles of HP*1 are called HP*1F (fast) and HP*1S (slow).||SIMILARITY:Belongs to the peptidase S1 family.||SIMILARITY:Contains 1 peptidase S1 domain.||SIMILARITY:Contains 2 Sushi (CCP/SCR) domains.||CAUTION:Although homologous to serine proteases, it has lost all essential catalytic residues and has no enzymatic activity.||WEB RESOURCE:Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/H |
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Subcellular localization |
Secreted. |
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Gene name |
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Related liver disease name |
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Protein sequence
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MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIA HGYVEHSVRYQCKNYYKLRTEGDGVYTLNDKKQWINKAV GDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLR TEGDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPAN PVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQW LLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEK VVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAE VGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHY EGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCY GDAGSAFAVHDLEEDTWYATGILSFDKSCAVAEYGVYVK VTSIQDWVQKTIAEN |
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Database cross reference |
RefSeq Protein accession:NP_001119574
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Liver relevance
| Liver sepcificity |
Yes/No |
Yes |
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Evidence |
UniProtein |
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Quality score |
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HCC significant Proteins |
Yes/No |
Yes |
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Quality score |
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HLPP validation |
Yes/No |
Yes |
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Project name |
Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005576;C:extracellular region;NAS:UniProtKB. GO:0031838;C:haptoglobin-hemoglobin complex;IDA:BHF-UCL. |
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GO-F |
GO:0030492;F:hemoglobin binding;IDA:BHF-UCL. GO:0004252;F:serine-type endopeptidase activity;IEA:InterPro. |
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GO-P |