Protein basic information
| LiverAtlas Protein ID |
HuLPr24825 |
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Uniprot ID |
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Uniprot Acc |
P04196;B9EK35;D3DNU7; |
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Protein name |
Histidine-rich glycoprotein |
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Comment |
FUNCTION:Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Inhibits rosette formation. Acts as an adapter protein and implicated in regulating many processes such as immune complex and pathogen clearance, cell adhesion, angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in an heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRG ligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities regulating their clearance and inhibiting the formation of insoluble immune complexes. Tethers plasminogen to the cell surface. Binds T-cells and alters the cell morphology. Modulates angiogenesis by blocking the CD6-mediated antiangiongenic effect of thrombospondins, THBS1 and THBS2.||SUBUNIT:Interac |
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Subcellular localization |
Secreted. |
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Gene name |
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Related liver disease name |
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Protein sequence
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MKALIAALLLITLQYSCAVSPTDCSAVEPEAEKALDLINK RRRDGYLFQLLRIADAHLDRVENTTVYYLVLDVQESDCS VLSRKYWNDCEPPDSRRPSEIVIGQCKVIATRHSHESQD LRVIDFNCTTSSVSSALANTKDSPVLIDFFEDTERYRKQ ANKALEKYKEENDDFASFRVDRIERVARVRGGEGTGYFV DFSVRNCPRHHFPRHPNVFGFCRADLFYDVEALDLESPK NLVINCEVFDPQEHENINGVPPHLGHPFHWGGHERSSTT KPPFKPHGSRDHHHPHKPHEHGPPPPPDERDHSHGPPLP QGPPPLLPMSCSSCQHATFGTNGAQRHSHNNNSSDLHPH KHHSHEQHPHGHHPHAHHPHEHDTHRQHPHGHHPHGHHP HGHHPHGHHPHGHHPHCHDFQDYGPCDPPPHNQGHCCHG HGPPPGHLRRRGPGKGPRPFHCRQIGSVYRLPPLRKGEV LPLPEANFPSFPLPHHKHPLKPDNQPFPQSVSESCPGKF KSGFPQVSMFFTHTFPK |
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Database cross reference |
RefSeq Protein accession:NP_000403
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Liver relevance
| Liver sepcificity |
Yes/No |
Yes |
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Evidence |
BodyMap |
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Quality score |
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HCC significant Proteins |
Yes/No |
Yes |
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Quality score |
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;French Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005576;C:extracellular region;NAS:UniProtKB. GO:0005886;C:plasma membrane;TAS:Reactome. GO:0031093;C:platelet alpha granule lumen;TAS:Reactome. |
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GO-F |
GO:0004869;F:cysteine-type endopeptidase inhibitor activity;IEA:InterPr |