HuLPr24838

Uniprot ID

HS3S2_HUMAN

Uniprot Acc

Q9Y278;Q52LZ1;

Protein name

Heparan sulfate glucosamine 3-O-sulfotransferase 2

Comment

FUNCTION:Transfers a sulfuryl group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.||CATALYTIC ACTIVITY:3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate.||SUBCELLULAR LOCATION:Golgi apparatus membrane; Single-pass type II membrane protein (Probable).||TISSUE SPECIFICITY:Highly expressed in the brain and weakly expressed in the heart, placenta, lung and skeletal muscle.||SIMILARITY:Belongs to the sulfotransferase 1 family.||WEB RESOURCE:Name=GGDB; Note=GlycoGene database; URL="http://riodb.ibase.aist.go.jp/rcmg/ggdb/";

Subcellular localization

Golgi apparatus membrane;Single-pass type II membrane protein(Probable).

Gene name

heparan sulfate (glucosamine) 3-O-sulfotransferase 2

Protein sequence

MAYRVLGRAGPPQPRRARRLLFAFTLSLSCTYLCYSFLCC CDDLGRSRLLGAPRCLRGPSAGGQKLLQKSRPCDPSGPT PSEPSAPSAPAAAVPAPRLSGSNHSGSPKLGTKRLPQAL IVGVKKGGTRAVLEFIRVHPDVRALGTEPHFFDRNYGRG LDWYRSLMPRTLESQITLEKTPSYFVTQEAPRRIFNMSR DTKLIVVVRNPVTRAISDYTQTLSKKPDIPTFEGLSFRN RTLGLVDVSWNAIRIGMYVLHLESWLQYFPLAQIHFVSG ERLITDPAGEMGRVQDFLGIKRFITDKHFYFNKTKGFPC LKKTESSLLPRCLGKSKGRTHVQIDPEVIDQLREFYRPY NIKFYETVGQDFRWE

Database cross reference

RefSeq Protein accession:NP_006034
RefSeq Protein gi:5174463

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Fetal Liver;Human Liver Organelles;

GO:0000139;C:Golgi membrane;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;TAS:ProtInc.

GO-F

GO:0033871;F:[heparan sulfate]-glucosamine 3-sulfotransferase 2 activity;IEA:EC.