HuLPr24849

Uniprot ID

HS90A_HUMAN

Uniprot Acc

P07900;A8K500;B3KPJ9;Q2PP14;Q5CAQ6;Q5CAQ7;Q9BVQ5;

Protein name

Heat shock protein HSP 90-alpha

Comment

FUNCTION:Molecular chaperone. Has ATPase activity (By similarity).||SUBUNIT:Homodimer. Interacts with AHSA1, FNIP1, HSF1, SMYD3 and TOM34. Interacts with TERT; the interaction, together with PTGES3/P23, is required for correct assembly and stabilization of the TERT holoenzyme complex. Interacts with CHORDC1 and DNAJC7.||INTERACTION:Q9UHD1:CHORDC1; NbExp=2; IntAct=EBI-296047, EBI-2550959; P07901:Hsp90aa1 (xeno); NbExp=1; IntAct=EBI-296047, EBI-78930; Q96G23:LASS2; NbExp=1; IntAct=EBI-296047, EBI-1057080; O15116:LSM1; NbExp=1; IntAct=EBI-296047, EBI-347619; P08253:MMP2; NbExp=1; IntAct=EBI-296047, EBI-1033518; Q92597:NDRG1; NbExp=1; IntAct=EBI-296047, EBI-716486; P61247:RPS3A; NbExp=1; IntAct=EBI-296047, EBI-352378; Q9UNE7:STUB1; NbExp=2; IntAct=EBI-296047, EBI-357085;||SUBCELLULAR LOCATION:Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=HSP90

Subcellular localization

Cytoplasm.Melanosome.

Gene name

heat shock protein 90kDa alpha (cytosolic), class A member 1

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSN KEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHIN LIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAF MEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDD EQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTE YLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEA EEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKKDGDK KKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFY KSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLF ENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDS EDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAED KENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSA SGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFV ERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKE GLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKV VVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTM GYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVI LLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDP TADDTSAAVTEEMPPLEGDDDTSRMEEVD

Database cross reference

RefSeq Protein accession:NP_001017963
RefSeq Protein gi:153792590

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Human Fetal Liver;Chinese Liver;Human Liver Organelles;French Liver;

GO:0005829;C:cytosol;NAS:UniProtKB. GO:0042470;C:melanosome;IEA:UniProtKB-SubCell. GO:0005886;C:plasma membrane;EXP:Reactome.

GO-F

GO:0005524;F:ATP binding;TAS:UniProtKB. GO:0016887;F:ATPase activity;IDA:UniProtKB. GO:0030235;F:nitric-oxide synthase regulator activity;IDA:UniProtKB. GO:0042803;F:protein homodimerization activity;TAS:UniProtKB. GO:0030911;F:TPR domain binding;IDA:U

GO-P

GO:0007411;P:axon guidance;TAS:Reactome. GO:0034619;P:cellular chaperone-mediated protein complex assembly;IDA:BHF-UCL. GO:0000086;P:G2/M transition of mitotic cell cycle;TAS:Reactome. GO:0046209;P:nitric oxide metabolic process;TAS:Reactome. GO:004542