Protein basic information
| LiverAtlas Protein ID |
HuLPr24871 |
|
Uniprot ID |
|
|
Uniprot Acc |
P11142;Q9H3R6; |
|
Protein name |
Heat shock cognate 71 kDa protein |
|
Comment |
FUNCTION:Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing the co- chaperones.||SUBUNIT:Interacts with HSPH1/HSP105. Interacts with IRAK1BP1 (By similarity). Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with PACRG and TSC2. Interacts with BAG1. Interacts with SV40 VP1. Interacts with DNAJC7 (By similarity). Interacts with HERC5. Interacts with CITED1 (via N-terminus); the interaction suppresses the association of CITED1 to p300/CBP and Smad-mediated transcription transactivation.||INTERACTION:P49407:ARRB1; NbExp=1; IntAct=EBI-351896, EBI-7433 |
|
Subcellular localization |
Cytoplasm.Melanosome. |
|
Gene name |
|
|
Related liver disease name |
|
|
Protein sequence
|
MSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPS YVAFTDTERLIGDAAKNQVAMNPTNTVFDAKRLIGRRFD DAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEE VSSMVLTKMKEIAEAYLGKTVTNAVVTVPAYFNDSQRQA TKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNVL IFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDN RMVNHFIAEFKRKHKKDISENKRAVRRLRTACERAKRTL SSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGT LDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQD FFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDL LLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTT YSDNQPGVLIQVYEGERAMTKDNNLLGKFELTGIPPAPR GVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKG RLSKEDIERMVQEAEKYKAEDEKQRDKVSSKNSLESYAF NMKATVEDEKLQGKINDEDKQKILDKCNEIINWLDKNQT AEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPGGF PGGGAPPSGGASSGPTIEEVD |
|
Database cross reference |
RefSeq Protein accession:NP_006588
|
Liver relevance
|
HCC significant Proteins |
Yes/No |
Yes |
|
Quality score |
|
|
|
HLPP validation |
Yes/No |
Yes |
|
Project name |
Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0009986;C:cell surface;IDA:UniProtKB. GO:0061202;C:clathrin sculpted gamma-aminobutyric acid transport vesicle membrane;EXP:Reactome. GO:0005829;C:cytosol;TAS:Reactome. GO:0042470;C:melanosome;IEA:UniProtKB-SubCell. GO:0005886;C:plasma membrane;TAS: |
|
GO-F |
GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0042623;F:ATPase activity, coupled;NAS:UniProtKB. GO:0005515;F:protein binding;IPI:UniProtKB. GO:0016564;F:transcription repressor activity;IDA:UniProtKB. |
|
GO-P |
GO:0016044;P:cellular membrane organization;EXP:Reactome. GO:0044419;P:interspecies interaction between organisms;IEA:UniProtKB-KW. GO:0016071;P:mRNA metabolic process;TAS:Reactome. GO:0007269;P:neurotransmitter secretion;TAS:Reactome. GO:0006892;P:pos |