Choose one of the five choices you want to search:

Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr24988

Uniprot ID

I17RD_HUMAN

Uniprot Acc

Q8NFM7;Q2NKP7;Q58EZ7;Q6RVF4;Q6UWI5;Q8N113;Q8NFS0;Q9UFA0;

Protein name

Interleukin-17 receptor D

Comment

FUNCTION:Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK. Mediates JNK activation and may be involved in apoptosis (By similarity).||SUBUNIT:Interacts with MAP3K7 (By similarity). Self-associates. Interacts with FGFR1, FGFR2 and phosphorylated MAP2K1 or MAP2K2. Associates with a MAP2K1/2-MAPK1/3 complex.||SUBCELLULAR LOCATION:Golgi apparatus membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Note=Predominantly associated with the Golgi apparatus and is partially translocated to the plasma membrane upon stimulation.||SUBCELLULAR LOCATION:Isoform 4:Cytoplasm.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=hSef-a, IL17RLM-L, Long; IsoId=Q8NFM7-1

Subcellular localization

Golgi apparatus membrane;Single-pass type I membrane protein.Cell membrane;Single-pass type I membrane protein.

Gene name

interleukin 17 receptor D

Protein sequence

MAPWLQLCSVFFTVNACLNGSQLAVAAGGSGRARGADTCG WRGVGPASRNSGLYNITFKYDNCTTYLNPVGKHVIADAQ NITISQYACHDQVAVTILWSPGALGIEFLKGFRVILEEL KSEGRQCQQLILKDPKQLNSSFKRTGMESQPFLNMKFET DYFVKVVPFPSIKNESNYHPFFFRTRACDLLLQPDNLAC KPFWKPRNLNISQHGSDMQVSFDHAPHNFGFRFFYLHYK LKHEGPFKRKTCKQEQTTETTSCLLQNVSPGDYIIELVD DTNTTRKVMHYALKPVHSPWAGPIRAVAITVPLVVISAF ATLFTVMCRKKQQENIYSHLDEESSESSTYTAALPRERL RPRPKVFLCYSSKDGQNHMNVVQCFAYFLQDFCGCEVAL DLWEDFSLCREGQREWVIQKIHESQFIIVVCSKGMKYFV DKKNYKHKGGGRGSGKGELFLVAVSAIAEKLRQAKQSSS AALSKFIAVYFDYSCEGDVPGILDLSTKYRLMDNLPQLC SHLHSRDHGLQEPGQHTRQGSRRNYFRSKSGRSLYVAIC NMHQFIDEEPDWFEKQFVPFHPPPLRYREPVLEKFDSGL VLNDVMCKPGPESDFCLKVEAAVLGATGPADSQHESQHG GLDQDGEARPALDGSAALQPLLHTVKAGSPSDMPRDSGI YDSSVPSSELSLPLMEGLSTDQTETSSLTESVSSSSGLG EEEPPALPSKLLSSGSCKADLGCRSYTDELHAVAPL

Database cross reference

RefSeq Protein accession:NP_060033
RefSeq Protein gi:166063983

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0000139;C:Golgi membrane;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005886;C:plasma membrane;IEA:UniProtKB-SubCell.

GO-F

GO:0004872;F:receptor activity;IEA:UniProtKB-KW.

Post-translational modification

LiverAtlas Protein ID

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr24988

PHOSPHORYLATION

435

Y

PhosphoSitePlus

1020085

LTP

HTP

N

Pathway

Pathway name

FGF_signaling_pathway