HuLPr24995

Uniprot ID

I22R1_HUMAN

Uniprot Acc

Q8N6P7;A8K839;B2R9Y9;Q9HB22;

Protein name

Interleukin-22 receptor subunit alpha-1

Comment

FUNCTION:Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.||SUBUNIT:Heterodimer with IL10RB and with IL20RB. IL22 binding to heterodimer is greater than binding to IL22RA1 alone.||SUBCELLULAR LOCATION:Membrane; Single-pass type I membrane protein.||TISSUE SPECIFICITY:Expressed in colon, liver, lung, pancreas and kidney. No expression in immune cells such as monocytes, T-cells, and NK-cells. Expressed in keratinocytes of normal skin as well as in psoriatic skin lesion. Detected in normal blood brain barrier endothelial cells as well as in multiple sclerosis lesions; Stron

Subcellular localization

Membrane;Single-pass type I membrane protein.

Gene name

interleukin 22 receptor, alpha 1

Protein sequence

MRTLLTILTVGSLAAHAPEDPSDLLQHVKFQSSNFENILT WDSGPEGTPDTVYSIEYKTYGERDWVAKKGCQRITRKSC NLTVETGNLTELYYARVTAVSAGGRSATKMTDRFSSLQH TTLKPPDVTCISKVRSIQMIVHPTPTPIRAGDGHRLTLE DIFHDLFYHLELQVNRTYQMHLGGKQREYEFFGLTPDTE FLGTIMICVPTWAKESAPYMCRVKTLPDRTWTYSFSGAF LFSMGFLVAVLCYLSYRYVTKPPAPPNSLNVQRVLTFQP LRFIQEHVLIPVFDLSGPSSLAQPVQYSQIRVSGPREPA GAPQRHSLSEITYLGQPDISILQPSNVPPPQILSPLSYA PNAAPEVGPPSYAPQVTPEAQFPFYAPQAISKVQPSSYA PQATPDSWPPSYGVCMEGSGKDSPTGTLSSPKHLRPKGQ LQKEPPAGSCMLGGLSLQEVTSLAMEESQEAKSLHQPLG ICTDRTSDPNVLHSGEEGTPQYLKGQLPLLSSVQIEGHP MSLPLQPPSRPCSPSDQGPSPWGLLESLVCPKDEAKSPA PETSDLEQPTELDSLFRGLALTVQWES

Database cross reference

RefSeq Protein accession:NP_067081
RefSeq Protein gi:31317239

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW.

GO-F

GO:0004904;F:interferon receptor activity;TAS:UniProtKB.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr24995

PHOSPHORYLATION

251

Y

PhosphoSitePlus

15512803

LTP

N

HuLPr24995

PHOSPHORYLATION

421

S

PhosphoSitePlus

10942133

LTP

N

HuLPr24995

PHOSPHORYLATION

301

Y

PhosphoSitePlus

3579176

LTP

HTP

N

JAK-STAT