HuLPr24996

Uniprot ID

I22R2_HUMAN

Uniprot Acc

Q969J5;Q08AH7;Q6UWM1;Q96A41;Q96QR0;

Protein name

Interleukin-22 receptor subunit alpha-2

Comment

FUNCTION:Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.||FUNCTION:Isoform 1 may play a role in establishing and maintaining successful pregnancy.||SUBCELLULAR LOCATION:Secreted.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Long, CRF2-10L, CRF2-s1-long; IsoId=Q969J5-1; Sequence=Displayed; Name=2; Synonyms=Short, CRF2-10, CRF2-s1-short; IsoId=Q969J5-2; Sequence=VSP 013105; Name=3; Synonyms=CRF2-10S; IsoId=Q969J5-3; Sequence=VSP 013105, VSP 013106, VSP 013107;||TISSUE SPECIFICITY:Expressed in placenta, spleen, breast, skin and lung. Also detected in intestinal tract, testis, brain, heart and thymus. No expression found in prostate, bladder, kidney, ovary, muscle, bone marrow, liver and uterus. Isoform 1 is expressed only in placenta. Isoform 2 is expr

Subcellular localization

Secreted.

Gene name

interleukin 22 receptor, alpha 2

Protein sequence

MMPKHCFLGFLISFFLTGVAGTQSTHESLKPQRVQFQSRN FHNILQWQPGRALTGNSSVYFVQYKIMFSCSMKSSHQKP SGCWQHISCNFPGCRTLAKYGQRQWKNKEDCWGTQELSC DLTSETSDIQEPYYGRVRAASAGSYSEWSMTPRFTPWWE TKIDPPVMNITQVNGSLLVILHAPNLPYRYQKEKNVSIE DYYELLYRVFIINNSLEKEQKVYEGAHRAVEIEALTPHS SYCVVAEIYQPMLDRRSQRSEERCVEIP

Database cross reference

RefSeq Protein accession:NP_443194
RefSeq Protein gi:16418459

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;

GO:0005615;C:extracellular space;NAS:UniProtKB.

GO-F

GO:0042018;F:interleukin-22 receptor activity;IDA:UniProtKB.

GO-P

GO:0042516;P:regulation of tyrosine phosphorylation of Stat3 protein;ISS:UniProtKB.

JAK-STAT