HuLPr25031

Uniprot ID

ICOS_HUMAN

Uniprot Acc

Q9Y6W8;Q8N6W8;

Protein name

Inducible T-cell costimulator

Comment

FUNCTION:Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up- regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre- activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).||SUBUNIT:Homodimer; disulfide-linked.||SUBCELLULAR LOCATION:Isoform 1:Cell membrane; Single-pass type I membrane protein (Potential).||SUBCELLULAR LOCATION:Isoform 2:Secreted (Potential).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y6W8-1; Sequence=Displayed; Name=2; IsoId=Q9Y6W8-2; Sequence=VSP 010788; Note=No experimental confirmation ava

Subcellular localization

Isoform 1:Cell membrane;Single-pass type I membrane protein(Potential).

Gene name

inducible T-cell co-stimulator

Protein sequence

MKSGLWYFFLFCLRIKVLTGEINGSANYEMFIFHNGGVQI LCKYPDIVQQFKMQLLKGGQILCDLTKTKGSGNTVSIKS LKFCHSQLSNNSVSFFLYNLDHSHANYYFCNLSIFDPPP FKVTLTGGYLHIYESQLCCQLKFWLPIGCAAFVVVCILG CILICWLTKKKYSSSVHDPNGEYMFMRAVNTAKKSRLTDVTL

Database cross reference

RefSeq Protein accession:NP_036224
RefSeq Protein gi:15029518

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

GO:0005576;C:extracellular region;IEA:UniProtKB-SubCell.

GO-P

GO:0006955;P:immune response;NAS:UniProtKB. GO:0031295;P:T cell costimulation;TAS:Reactome.

TGF_beta_Receptor