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Protein basic information

LiverAtlas Protein ID

HuLPr25094

Uniprot ID

IFI6_HUMAN

Uniprot Acc

P09912;Q13141;Q13142;Q5VVR3;Q969M8;

Protein name

Interferon alpha-inducible protein 6

Comment

SUBCELLULAR LOCATION:Membrane; Multi-pass membrane protein (Potential).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=A; IsoId=P09912-1; Sequence=Displayed; Name=B; IsoId=P09912-2; Sequence=VSP 001502; Name=C; IsoId=P09912-3; Sequence=VSP 001503;||INDUCTION:By alpha and beta interferons.||SIMILARITY:Belongs to the IFI6/IFI27 family.

Subcellular localization

Membrane;Multi-pass membrane protein(Potential).

Gene name

interferon, alpha-inducible protein 6

Protein sequence

MRQKAVSLFLCYLLLFTCSGVEAGKKKCSESSDSGSGFWK ALTFMAVGGGLAVAGLPALGFTGAGIAANSVAASLMSWS AILNGGGVPAGGLVATLQSLGAGGSSVVIGNIGALMGYA THKYLDSEEDEE

Database cross reference

RefSeq Protein accession:NP_002029
RefSeq Protein gi:13259552

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005739;C:mitochondrion;IDA:HGNC.

GO-F

GO:0005515;F:protein binding;IPI:HGNC.

GO-P

GO:0006916;P:anti-apoptosis;IMP:HGNC. GO:0043154;P:negative regulation of caspase activity;IMP:HGNC. GO:0051902;P:negative regulation of mitochondrial depolarization;IMP:HGNC. GO:0001836;P:release of cytochrome c from mitochondria;IMP:HGNC. GO:0060337;

Pathway

Pathway name

IL4