HuLPr25149

Uniprot ID

IGHG3_HUMAN

Uniprot Acc

P01860;A2NU35;

Protein name

Ig gamma-3 chain C region

Comment

SUBUNIT:Dimer linked by 12 disulfide bonds; it has an extra interchain disulfide bond at position 7 in addition to the 11 normally present in the hinge region.||SUBCELLULAR LOCATION:Secreted.||MISCELLANEOUS:Disease protein WIS is lacking most of the V region and all of the CH1 region.||MISCELLANEOUS:Disease protein ZUC lack most of the V region, all of the CH1 region, and part of the hinge compared with normal gamma-3 heavy chains.||MISCELLANEOUS:Disease protein OMM may represent an allelic form or another gamma chain subclass.||MISCELLANEOUS:The hinge region in gamma-3 chains is about four times as long as in other gamma chains and contains three identical 15-residue segments preceded by a similar 17-residue segment (12-28).||SEQUENCE CAUTION:Sequence=CAA27268.1; Type=Erroneous initiation;||WEB RESOURCE:Name=IMGT/GENE-DB; URL="http://www.imgt.org/IMGT GENE-DB/GENElect?query=2+IGHG3&species=Homo+sapiens";

Subcellular localization

Secreted.

Gene name

immunoglobulin heavy constant gamma 3 (G3m marker)

Protein sequence

ASTKGPSVFPLAPCSRSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQ TYTCNVNHKPSNTKVDKRVELKTPLGDTTHTCPRCPEPK SCDTPPPCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCP RCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDV SHEDPEVQFKWYVDGVEVHNAKTKPREEQYNSTFRVVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKTKGQPR EPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWES SGQPENNYNTTPPMLDSDGSFFLYSKLTVDKSRWQQGNI FSCSVMHEALHNRFTQKSLSLSPGK

Database cross reference

HLPP validation

Yes/No

Yes

Project name

French Liver;Human Liver Organelles;

GO:0005576;C:extracellular region;IEA:UniProtKB-SubCell. GO:0005624;C:membrane fraction;NAS:UniProtKB.

GO-F

GO:0003823;F:antigen binding;IEA:UniProtKB-KW.

GO-P

GO:0006955;P:immune response;NAS:UniProtKB.

IL4-mediated_signaling_events

Notch_signaling_pathway