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Protein basic information

LiverAtlas Protein ID

HuLPr25163

Uniprot ID

IGSF8_HUMAN

Uniprot Acc

Q969P0;Q8NG09;Q96DP4;Q9BTG9;

Protein name

Immunoglobulin superfamily member 8

Comment

FUNCTION:May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility:suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin- dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain.||SUBUNIT:Interacts directly with CD82, CD81/tetraspanin-28 and CD9/tetraspanin-29. Also interacts with integrin alpha-3/beta-1 and integrin alpha-4/beta-1.||SUBCELLULAR LOCATION:Membrane; Single-pass membrane protein (Potential).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q969P0-1; Sequence=Displayed; Na

Subcellular localization

Membrane;Single-pass membrane protein(Potential).

Gene name

immunoglobulin superfamily, member 8

Protein sequence

MGALRPTLLPPSLPLLLLLMLGMGCWAREVLVPEGPLYRV AGTAVSISCNVTGYEGPAQQNFEWFLYRPEAPDTALGIV STKDTQFSYAVFKSRVVAGEVQVQRLQGDAVVLKIARLQ AQDAGIYECHTPSTDTRYLGSYSGKVELRVLPDVLQVSA APPGPRGRQAPTSPPRMTVHEGQELALGCLARTSTQKHT HLAVSFGRSVPEAPVGRSTLQEVVGIRSDLAVEAGAPYA ERLAAGELRLGKEGTDRYRMVVGGAQAGDAGTYHCTAAE WIQDPDGSWAQIAEKRAVLAHVDVQTLSSQLAVTVGPGE RRIGPGEPLELLCNVSGALPPAGRHAAYSVGWEMAPAGA PGPGRLVAQLDTEGVGSLGPGYEGRHIAMEKVASRTYRL RLEAARPGDAGTYRCLAKAYVRGSGTRLREAASARSRPL PVHVREEGVVLEAVAWLAGGTVYRGETASLLCNISVRGG PPGLRLAASWWVERPEDGELSSVPAQLVGGVGQDGVAEL GVRPGGGPVSVELVGPRSHRLRLHSLGPEDEGVYHCAPS AWVQHADYSWYQAGSARSGPVTVYPYMHALDTLFVPLLV GTGVALVTGATVLGTITCCFMKRLRKR

Database cross reference

RefSeq Protein accession:NP_443100
RefSeq Protein gi:16445029

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0016021;C:integral to membrane;IDA:UniProtKB.

GO-F

GO:0005515;F:protein binding;IPI:UniProtKB.

GO-P

GO:0008283;P:cell proliferation;NAS:UniProtKB. GO:0006928;P:cellular component movement;NAS:UniProtKB. GO:0007399;P:nervous system development;NAS:UniProtKB. GO:0007338;P:single fertilization;NAS:UniProtKB. GO:0007519;P:skeletal muscle tissue developme

Pathway

Pathway name

Alpha4_beta1_integrin_signaling_events

Pathway name

Beta1_integrin_cell_surface_interactions