HuLPr25172

Uniprot ID

IKBZ_HUMAN

Uniprot Acc

Q9BYH8;B3KNR2;D3DN54;Q8IUL4;Q8NAZ8;

Protein name

NF-kappa-B inhibitor zeta

Comment

FUNCTION:Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF- kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis (By similarity).||SUBUNIT:Interacts with NFKB1/p50. Interacts with RELA.||SUBCELLULAR LOCATION:Nucleus. Note=Aggregated in dot-like structures. Colocalizes with NCOR2.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; N

Subcellular localization

Nucleus.

Gene name

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta

Protein sequence

MIVDKLLDDSRGGEGLRDAAGGCGLMTSPLNLSYFYGASP PAAAPGACDASCSVLGPSAPGSPGSDSSDFSSASSVSSC GAVESRSRGGARAERQPVEPHMGVGRQQRGPFQGVRVKN SVKELLLHIRSHKQKASGQAVDDFKTQGVNIEQFRELKN TVSYSGKRKGPDSLSDGPACKRPALLHSQFLTPPQTPTP GESMEDVHLNEPKQESSADLLQNIINIKNECSPVSLNTV QVSWLNPVVVPQSSPAEQCQDFHGGQVFSPPQKCQPFQV RGSQQMIDQASLYQYSPQNQHVEQQPHYTHKPTLEYSPF PIPPQSPAYEPNLFDGPESQFCPNQSLVSLLGDQRESEN IANPMQTSSSVQQQNDAHLHSFSMMPSSACEAMVGHEMA SDSSNTSLPFSNMGNPMNTTQLGKSLFQWQVEQEESKLA NISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNA LHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNT TDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEA TNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLL KNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEAN LELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLT QLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQQRAPPY

Database cross reference

RefSeq Protein accession:NP_001005474
RefSeq Protein gi:53832024

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0005634;C:nucleus;IEA:UniProtKB-SubCell.

GO-P

GO:0006355;P:regulation of transcription, DNA-dependent;IEA:UniProtKB-KW. GO:0006351;P:transcription, DNA-dependent;IEA:UniProtKB-KW.