HuLPr25179

Uniprot ID

IKZF3_HUMAN

Uniprot Acc

Q9UKT9;Q69BL6;Q69BL7;Q69BL8;Q69BL9;Q69BM0;Q69BM1;Q69BM2;Q69BM3;Q69BM5;Q8N574;Q8WWQ9;Q8WWR0;Q8WWR1;Q8WWR2;Q8WWR3;

Protein name

Zinc finger protein Aiolos

Comment

FUNCTION:Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2- dependent manner.||SUBUNIT:Homodimer, and heterodimer with other IKAROS family members. Interacts with IKZF4 AND IKZF5. Interacts with IKZF1. Interacts with HRAS. Interacts with FOXP3; this interaction may be required for silencing target genes and regulating the suppressive activity of FOXP3-positive regulatory T-cells (Treg). Interacts with BCL21L isoform Bcl-X(L); this interaction blocks the anti- apoptotic role of BCL21L. Associates with histone deacetylase complexes containing HDAC1, MTA2 and SIN3A.||SUBCELLULAR LOCATION:Nucleus. Cytoplasm.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=15; Name=1; Synonyms=Aio-1; IsoId=Q9UKT9-1; Sequence=Displayed; Name=2

Subcellular localization

Nucleus.Cytoplasm.

Gene name

IKAROS family zinc finger 3 (Aiolos)

Protein sequence

MEDIQTNAELKSTQEQSVPAESAAVLNDYSLTKSHEMENV DSGEGPANEDEDIGDDSMKVKDEYSERDENVLKSEPMGN AEEPEIPYSYSREYNEYENIKLERHVVSFDSSRPTSGKM NCDVCGLSCISFNVLMVHKRSHTGERPFQCNQCGASFTQ KGNLLRHIKLHTGEKPFKCHLCNYACQRRDALTGHLRTH SVEKPYKCEFCGRSYKQRSSLEEHKERCRTFLQSTDPGD TASAEARHIKAEMGSERALVLDRLASNVAKRKSSMPQKF IGEKRHCFDVNYNSSYMYEKESELIQTRMMDQAINNAIS YLGAEALRPLVQTPPAPTSEMVPVISSMYPIALTRAEMS NGAPQELEKKSIHLPEKSVPSERGLSPNNSGHDSTDTDS NHEERQNHIYQQNHMVLSRARNGMPLLKEVPRSYELLKP PPICPRDSVKVINKEGEVMDVYRCDHCRVLFLDYVMFTI HMGCHGFRDPFECNMCGYRSHDRYEFSSHIARGEHRALLK

Database cross reference

RefSeq Protein accession:NP_036613
RefSeq Protein gi:33589816

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;French Liver;

GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell. GO:0005634;C:nucleus;IEA:UniProtKB-SubCell.

GO-F

GO:0003677;F:DNA binding;IEA:UniProtKB-KW. GO:0003700;F:sequence-specific DNA binding transcription factor activity;TAS:ProtInc. GO:0008270;F:zinc ion binding;IEA:InterPro.

GO-P

GO:0042113;P:B cell activation;IEA:UniProtKB-KW. GO:0007498;P:mesoderm development;TAS:ProtInc. GO:0006357;P:regulation of transcription from RNA polymerase II promoter;TAS:ProtInc.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr25179

PHOSPHORYLATION

169

T

Phospho-ELM

42561

HTP

N

HuLPr25179

PHOSPHORYLATION

57

S

PhosphoSitePlus

14735925

LTP

N

HuLPr25179

PHOSPHORYLATION

169

T

PhosphoSitePlus

1244652

LTP

N

HuLPr25179

PHOSPHORYLATION

286

Y

PhosphoSitePlus

484643

LTP

HTP

N

HuLPr25179

PHOSPHORYLATION

290

Y

PhosphoSitePlus

484644

LTP

N

IL2-mediated_signaling_events