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Protein basic information

LiverAtlas Protein ID

HuLPr25201

Uniprot ID

IL1FA_HUMAN

Uniprot Acc

Q8WWZ1;Q53SR9;Q56AT8;Q7RTZ5;Q969H5;Q9BYX1;

Protein name

Interleukin-1 family member 10

Comment

FUNCTION:Binds soluble IL-1 receptor type 1.||SUBCELLULAR LOCATION:Secreted.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8WWZ1-1; Sequence=Displayed; Name=2; IsoId=Q8WWZ1-2; Sequence=VSP 002658; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Expressed in fetal skin, spleen and tonsil. Expressed mostly in the basal epithelia of skin and in proliferating B-cells of the tonsil.||SIMILARITY:Belongs to the IL-1 family.||WEB RESOURCE:Name=Wikipedia; Note=Interleukin-1 entry; URL="http://en.wikipedia.org/wiki/Interleukin 1";||WEB RESOURCE:Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il1f10/";

Subcellular localization

Secreted.

Gene name

interleukin 1 family, member 10 (theta)

Protein sequence

MCSLPMARYYIIKYADQKALYTRDGQLLVGDPVADNCCAE KICILPNRGLARTKVPIFLGIQGGSRCLACVETEEGPSL QLEDVNIEELYKGGEEATRFTFFQSSSGSAFRLEAAAWP GWFLCGPAEPQQPVQLTKESEPSARTKFYFEQSW

Database cross reference

RefSeq Protein accession:NP_115945
RefSeq Protein gi:27894304

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005615;C:extracellular space;IEA:UniProtKB-KW.

GO-F

GO:0005125;F:cytokine activity;IEA:UniProtKB-KW. GO:0005152;F:interleukin-1 receptor antagonist activity;IEA:InterPro.