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Protein basic information

LiverAtlas Protein ID

HuLPr25211

Uniprot ID

IL23R_HUMAN

Uniprot Acc

Q5VWK5;C9JGX4;Q4VGP1;Q4VGP2;Q4VGP3;Q4VGP4;Q4VGP5;Q4VGP6;Q5VWK7;Q8IW84;Q8NFQ9;Q96AS1;

Protein name

Interleukin-23 receptor

Comment

FUNCTION:Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.||SUBUNIT:Heterodimer with IL12RB1. In presence of IL23, the heterodimer forms the IL23 receptor. Interacts with JAK2 and in presence of IL23 with STAT3.||SUBCELLULAR LOCATION:Cell membrane; Single-pass type I membrane protein.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=7; Name=1; Synonyms=IL-23R1; IsoId=Q5VWK5-1; Sequence=Displayed; Name=2; Synonyms=IL-23R2-F2; IsoId=Q5VWK5-2; Sequence=VSP 021993; Note=Produced by translation in an alternate frame of the cDNA encoding isoform 4. No experimental confirmation availa

Subcellular localization

Cell membrane;Single-pass type I membrane protein.

Gene name

interleukin 23 receptor

Protein sequence

MNQVTIQWDAVIALYILFSWCHGGITNINCSGHIWVEPAT IFKMGMNISIYCQAAIKNCQPRKLHFYKNGIKERFQITR INKTTARLWYKNFLEPHASMYCTAECPKHFQETLICGKD ISSGYPPDIPDEVTCVIYEYSGNMTCTWNAGKLTYIDTK YVVHVKSLETEEEQQYLTSSYINISTDSLQGGKKYLVWV QAANALGMEESKQLQIHLDDIVIPSAAVISRAETINATV PKTIIYWDSQTTIEKVSCEMRYKATTNQTWNVKEFDTNF TYVQQSEFYLEPNIKYVFQVRCQETGKRYWQPWSSLFFH KTPETVPQVTSKAFQHDTWNSGLTVASISTGHLTSDNRG DIGLLLGMIVFAVMLSILSLIGIFNRSFRTGIKRRILLL IPKWLYEDIPNMKNSNVVKMLQENSELMNNNSSEQVLYV DPMITEIKEIFIPEHKPTDYKKENTGPLETRDYPQNSLF DNTTVVYIPDLNTGYKPQISNFLPEGSHLSNNNEITSLT LKPPVDSLDSGNNPRLQKHPNFAFSVSSVNSLSNTIFLG ELSLILNQGECSSPDIQNSVEEETTMLLENDSPSETIPE QTLLPDEFVSCLGIVNEELPSINTYFPQNILESHFNRISLLEK

Database cross reference

RefSeq Protein accession:NP_653302
RefSeq Protein gi:24430212

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0072536;C:interleukin-23 receptor complex;IDA:BHF-UCL.

GO-F

GO:0004872;F:receptor activity;IEA:UniProtKB-KW.

GO-P

GO:0050829;P:defense response to Gram-negative bacterium;IC:BHF-UCL. GO:0006954;P:inflammatory response;IEA:UniProtKB-KW. GO:0032693;P:negative regulation of interleukin-10 production;IMP:BHF-UCL. GO:0042104;P:positive regulation of activated T cell pro

Pathway

Pathway name

IL23-mediated_signaling_events

Pathway name

JAK-STAT