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Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr25214

Uniprot ID

IL27A_HUMAN

Uniprot Acc

Q8NEV9;A0N0L2;Q6P676;

Protein name

Interleukin-27 subunit alpha

Comment

FUNCTION:Cytokine with pro- and anti-inflammatory properties, that can regulate T helper cell development, suppress T-cell proliferation, stimulate cytotoxic T cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon- gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR which appears to be required but not sufficient for IL-27-mediated signal transduction. IL-27 potentiate the early phase of TH1 response and suppress TH2 and TH17 differentiation. It induces the differentiation of TH1 cells via two distinct pathways, p38 MAPK/TBX21- and ICAM1/ITGAL/ERK- dependent pathways. It also induces STAT1, STAT3, ST

Subcellular localization

Secreted.

Gene name

interleukin 27

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MGQTAGDLGWRLSLLLLPLLLVQAGVWGFPRPPGRPQLSL QELRREFTVSLHLARKLLSEVRGQAHRFAESHLPGVNLY LLPLGEQLPDVSLTFQAWRRLSDPERLCFISTTLQPFHA LLGGLGTQGRWTNMERMQLWAMRLDLRDLQRHLRFQVLA AGFNLPEEEEEEEEEEEEERKGLLPGALGSALQGPAQVS WPQLLSTYRLLHSLELVLSRAVRELLLLSKAGHSVWPLG FPTLSPQP

Database cross reference

RefSeq Protein accession:NP_663634
RefSeq Protein gi:28416913

Liver relevance

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;

Ontology annotation

GO-C

GO:0005615;C:extracellular space;ISS:UniProtKB.

GO-F

GO:0005125;F:cytokine activity;IEA:UniProtKB-KW. GO:0045523;F:interleukin-27 receptor binding;ISS:UniProtKB.

GO-P

GO:0006954;P:inflammatory response;IEA:UniProtKB-KW. GO:0045087;P:innate immune response;IEA:UniProtKB-KW. GO:0045078;P:positive regulation of interferon-gamma biosynthetic process;IDA:UniProtKB. GO:0050688;P:regulation of defense response to virus;IEA:

Pathway

Pathway name

IL27-mediated_signaling_events

Pathway name

JAK-STAT