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Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr25216

Uniprot ID

IL28B_HUMAN

Uniprot Acc

Q8IZI9;A2BDE1;Q6VN56;Q7Z4J3;Q8IWL6;

Protein name

Interleukin-28B

Comment

FUNCTION:Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway.||SUBCELLULAR LOCATION:Secreted.||INDUCTION:By viral infections or double-stranded RNA.||SIMILARITY:Belongs to the IL-28/IL-29 family.||SEQUENCE CAUTION:Sequence=AAN28264.1; Type=Erroneous initiation;

Subcellular localization

Secreted.

Gene name

interleukin 28B (interferon, lambda 3)

Protein sequence

MTGDCMPVLVLMAAVLTVTGAVPVARLRGALPDARGCHIA QFKSLSPQELQAFKRAKDALEESLLLKDCKCRSRLFPRT WDLRQLQVRERPVALEAELALTLKVLEATADTDPALGDV LDQPLHTLHHILSQLRACIQPQPTAGPRTRGRLHHWLHR LQEAPKKESPGCLEASVTFNLFRLLTRDLNCVASGDLCV

Database cross reference

RefSeq Protein accession:NP_742151
RefSeq Protein gi:28144901

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005615;C:extracellular space;IEA:UniProtKB-KW.

GO-F

GO:0005125;F:cytokine activity;IEA:UniProtKB-KW.

GO-P

GO:0009615;P:response to virus;IEA:UniProtKB-KW.

Pathway

Pathway name

JAK-STAT