HuLPr25217

Uniprot ID

IL29_HUMAN

Uniprot Acc

Q8IU54;A0AV25;Q17R34;

Protein name

Interleukin-29

Comment

FUNCTION:Cytokine with immunomodulatory activity. May play a role in antiviral immunity. Up-regulates MHC class I antigen expression. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway.||SUBCELLULAR LOCATION:Secreted.||INDUCTION:By viral infections or double-stranded RNA.||SIMILARITY:Belongs to the IL-28/IL-29 family.||WEB RESOURCE:Name=Wikipedia; Note=Interleukin-29 entry; URL="http://en.wikipedia.org/wiki/Interleukin 29";

Subcellular localization

Secreted.

Gene name

interleukin 29 (interferon, lambda 1)

Protein sequence

MAAAWTVVLVTLVLGLAVAGPVPTSKPTTTGKGCHIGRFK SLSPQELASFKKARDALEESLKLKNWSCSSPVFPGNWDL RLLQVRERPVALEAELALTLKVLEAAAGPALEDVLDQPL HTLHHILSQLQACIQPQPTAGPRPRGRLHHWLHRLQEAP KKESAGCLEASVTFNLFRLLTRDLKYVADGNLCLRTSTH PEST

Database cross reference

RefSeq Protein accession:NP_742152
RefSeq Protein gi:26024325

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;

GO:0005615;C:extracellular space;IEA:UniProtKB-KW. GO:0032002;C:interleukin-28 receptor complex;IDA:UniProtKB.

GO-F

GO:0005125;F:cytokine activity;IEA:UniProtKB-KW. GO:0032003;F:interleukin-28 receptor binding;IPI:UniProtKB.

GO-P

GO:0051607;P:defense response to virus;IDA:UniProtKB. GO:0008285;P:negative regulation of cell proliferation;IDA:UniProtKB. GO:0032696;P:negative regulation of interleukin-13 production;IDA:UniProtKB. GO:0032714;P:negative regulation of interleukin-5 pr

JAK-STAT