HuLPr25222

Uniprot ID

IL31R_HUMAN

Uniprot Acc

Q8NI17;A6NIF8;Q2TBA1;Q6EBC3;Q6EBC4;Q6EBC5;Q6EBC6;Q6UWL8;Q8WYJ0;

Protein name

Interleukin-31 receptor subunit alpha

Comment

FUNCTION:Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity.||SUBUNIT:Heterodimer with OSMR. Interacts with JAK1 and STAT3.||SUBCELLULAR LOCATION:Cell membrane; Single-pass type I membrane protein (Probable).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=12; Name=1; IsoId=Q8NI17-1; Sequence=Displayed; Name=2; Synonyms=v3; IsoId=Q8NI17-2; Sequence=VSP 022799; Name=3; Synonyms=v4; IsoId=Q8NI17-3; Sequence=VSP 022800, VSP 022812, VSP 022813; Name=4; Synonyms=v2; IsoId=Q8NI17-4; Sequence=VSP 022799, VSP 022801; Name=5; Synonyms=v1; IsoId=Q8NI17-5; Sequence=VSP 022799, VSP 022812, VSP 022813; Name=6; IsoId=Q8NI17-6; Sequence=VSP 022798; Note=No experimental confirmation available; Name=7; IsoId=Q8NI17-7; Sequence=VSP 022800, VSP 022802, VSP 022804, VSP 022805; Note=No experimental confirmation available; Name=8; IsoId=Q8NI17-8; Se

Subcellular localization

Cell membrane;Single-pass type I membrane protein(Probable).

Gene name

interleukin 31 receptor A

Protein sequence

MMWTWALWMLPSLCKFSLAALPAKPENISCVYYYRKNLTC TWSPGKETSYTQYTVKRTYAFGEKHDNCTTNSSTSENRA SCSFFLPRITIPDNYTIEVEAENGDGVIKSHMTYWRLEN IAKTEPPKIFRVKPVLGIKRMIQIEWIKPELAPVSSDLK YTLRFRTVNSTSWMEVNFAKNRKDKNQTYNLTGLQPFTE YVIALRCAVKESKFWSDWSQEKMGMTEEEAPCGLELWRV LKPAEADGRRPVRLLWKKARGAPVLEKTLGYNIWYYPES NTNLTETMNTTNQQLELHLGGESFWVSMISYNSLGKSPV ATLRIPAIQEKSFQCIEVMQACVAEDQLVVKWQSSALDV NTWMIEWFPDVDSEPTTLSWESVSQATNWTIQQDKLKPF WCYNISVYPMLHDKVGEPYSIQAYAKEGVPSEGPETKVE NIGVKTVTITWKEIPKSERKGIICNYTIFYQAEGGKGFS KTVNSSILQYGLESLKRKTSYIVQVMASTSAGGTNGTSI NFKTLSFSVFEIILITSLIGGGLLILIILTVAYGLKKPN KLTHLCWPTVPNPAESSIATWHGDDFKDKLNLKESDDSV NTEDRILKPCSTPSDKLVIDKLVVNFGNVLQEIFTDEAR TGQENNLGGEKNGYVTCPFRPDCPLGKSFEELPVSPEIP PRKSQYLRSRMPEGTRPEAKEQLLFSGQSLVPDHLCEEG APNPYLKNSVTAREFLVSEKLPEHTKGEV

Database cross reference

RefSeq Protein accession:NP_620586
RefSeq Protein gi:115430248

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0016021;C:integral to membrane;NAS:UniProtKB. GO:0005886;C:plasma membrane;IEA:UniProtKB-SubCell.

GO-F

GO:0004896;F:cytokine receptor activity;TAS:UniProtKB. GO:0019901;F:protein kinase binding;NAS:UniProtKB. GO:0003713;F:transcription coactivator activity;NAS:UniProtKB.

GO-P

GO:0006916;P:anti-apoptosis;NAS:UniProtKB. GO:0006952;P:defense response;NAS:UniProtKB. GO:0042592;P:homeostatic process;NAS:UniProtKB. GO:0007259;P:JAK-STAT cascade;IEP:UniProtKB. GO:0030225;P:macrophage differentiation;NAS:UniProtKB. GO:0000165;P:MA

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr25222

PHOSPHORYLATION

708

Y

PhosphoSitePlus

462394

LTP

HTP

N

JAK-STAT