Protein basic information
| LiverAtlas Protein ID |
HuLPr25237 |
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Uniprot ID |
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Uniprot Acc |
P40189;A0N0L4;Q9UQ41; |
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Protein name |
Interleukin-6 receptor subunit beta |
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Comment |
FUNCTION:Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events.||SUBUNIT:Interacts with INPP5D/SHIP1 (By similarity). Forms heterodimers composed of LIPR and IL6ST (type I OSM receptor). Also forms heterodimers composed of OSMR and IL6ST (type II OSM receptor). Homodimer. The homodimer binds two molecules of herpes virus IL6. Component of a hexamer of two molecules each of IL6, IL6R and IL6ST.||INTERACTION:P42227:Stat3 (xeno); NbExp=2; IntAct=EBI-1030834, EBI-602878; Q98823:vIL-6 (xeno); NbExp=1; IntAct=EBI-1030834, EBI-1030823;||SUBCELLULAR LOCATION:Isoform 1:Cell membrane; Single-pass type I membrane protein |
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Subcellular localization |
Isoform 1:Cell membrane;Single-pass type I membrane protein. |
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Gene name |
interleukin 6 signal transducer (gp130, oncostatin M receptor) |
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Related liver disease name |
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Protein sequence
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MLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQL HSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFTIPKEQY TIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGI TIISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETN FTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEV WVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEE LSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPP EDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDW SEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWK TLPPFEANGKILDYEVTLTRWKSHLQNYTVNATKLTVNL TNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDL KAFPKDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITD WQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPE SIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQ NGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDT LYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEAIVVPV CLAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPSKSHIA QWSPHTPPRHNFNSKDQMYSDGNFTDVSVVEIEANDKKP FPEDLKSLDLFKKEKINTEGHSSGIGGSSCMSSSRPSIS SSDENESSQNTSSTVQYSTVVHSGYRHQVPSVQVFSRSE STQPLLDSEERPEDLQLVDHVDGGDGILPRQQYFKQNCS QHESSPDISHFERSKQVSSVNEEDFVRLKQQISDHISQS CGSGQMKMFQEVSAADAFGPGTEGQVERFETVGMEAATDEGMPKSYLPQTVRQGGYMPQ |
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Database cross reference |
RefSeq Protein accession:NP_001177910
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Liver relevance
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HCC significant Proteins |
Yes/No |
Yes |
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Quality score |
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver; |
Ontology annotation
| GO-C |
GO:0070110;C:ciliary neurotrophic factor receptor complex;IDA:BHF-UCL. GO:0005576;C:extracellular region;EXP:Reactome. GO:0005615;C:extracellular space;IDA:BHF-UCL. GO:0005896;C:interleukin-6 receptor complex;IDA:BHF-UCL. GO:0005900;C:oncostatin-M rece |
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GO-F |
GO:0004897;F:ciliary neurotrophic factor receptor activity;IDA:BHF-UCL. GO:0005127;F:ciliary neurotrophic factor receptor binding;IPI:BHF-UCL. GO:0019838;F:growth factor binding;IPI:BHF-UCL. GO:0045509;F:interleukin-27 receptor activity;IC:BHF-UCL. GO: |
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GO-P |
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