Protein basic information
| LiverAtlas Protein ID |
HuLPr25304 |
|
Uniprot ID |
|
|
Uniprot Acc |
O15327;Q2TAI2;Q6IN59;Q6PJB4; |
|
Protein name |
Type II inositol-3,4-bisphosphate 4-phosphatase |
|
Comment |
FUNCTION:Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 1,4-bisphosphate.||CATALYTIC ACTIVITY:1-phosphatidyl-myo-inositol 3,4-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.||ENZYME REGULATION:Strongly inhibited by inositol hexakisphosphate (By similarity).||PATHWAY:Signal transduction; phosphatidylinositol signaling pathway.||TISSUE SPECIFICITY:Widely expressed with highest levels occurring in the skeletal muscle and heart.||SIMILARITY:Belongs to the inositol-3,4-bisphosphate 4-phosphatase family.||SIMILARITY:Contains 1 C2 domain.||SEQUENCE CAUTION:Sequence=AAH72447.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; |
|
Gene name |
|
|
Protein sequence
|
MEIKEEGASEEGQHFLPTAQANDPGDCQFTSIQKTPNEPQ LEFILACKDLVAPVRDRKLNTLVQISVIHPVEQSLTRYS STEIVEGTRDPLFLTGVTFPSEYPIYEETKIKLTVYDVK DKSHDTVRTSVLPEHKDPPPEVGRSFLGYASFKVGELLK SKEQLLVLSLRTSDGGKVVGTIEVSVVKMGEIEDGEADH ITTDVQGQKCALVCECTAPESVSGKDNLPFLNSVLKNPV CKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLHIK EDLCRNQEIKELGELSPHWDNLRKNVLTHCDQMVNMYQD ILTELSKETGSSFKSSSSKGEKTLEFVPINLHLQRMQVH SPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFETE RRNTGYQFIYYSPENTAKAKEVLSNINQLQPLIATHADL LLNSASQHSPDSLKNSLKMLSEKTELFVHAFKDQLVRSA LLALYTARPGGILKKPPSPKSSTEESSPQDQPPVMRGQD SIPHHSDYDEEEWDRVWANVGKSLNCIIAMVDKLIERDG GSEGSGGNNDGEKEPSLTDAIPSHPREDWYEQLYPLILT LKDCMGEVVNRAKQSLTFVLLQELAYSLPQCLMLTLRRD IVFSQALAGLVCGFIIKLQTSLYDPGFLQQLHTVGLIVQ YEGLLSTYSDEIGMLEDMAVGISDLKKVAFKIIEAKSND VLPVITGRREHYVVEVKLPARMFESLPLQIKEGQLLHVY PVLFNVGINEQQTLAERFGDVSLQESINQENFELLQEYY KIFMEKMPPDYISHFQEQNDLKALLENLLQNIQSKKRKN VEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLEQCS ILRDEHQLHKDFFIRALDCMRREGCRIENVLKNIKCRKY AFNMLQLMAFPKYYRPPEGTYGKADT |
|
Database cross reference |
RefSeq Protein accession:NP_001095139
|
Liver relevance
|
HLPP validation |
Yes/No |
Yes |
|
Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
|
GO-F |
GO:0016316;F:phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity;TAS:ProtInc. GO:0034597;F:phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity;IEA:EC. |
|
GO-P |
GO:0007165;P:signal transduction;TAS:ProtInc. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr25304 |
ACETYLATION |
448 |
K |
PhosphoSitePlus |
LTP |
N |
 
|
|
|
HuLPr25304 |
PHOSPHORYLATION |
898 |
Y |
PhosphoSitePlus |
LTP |
N |
|
Pathway
| Pathway name | |
| Pathway name | |
| Pathway name |
