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Protein basic information

LiverAtlas Protein ID

HuLPr25330

Uniprot ID

INT9_HUMAN

Uniprot Acc

Q9NV88;O00224;Q8TB16;

Protein name

Integrator complex subunit 9

Comment

FUNCTION:Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.||SUBUNIT:Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.||SUBCELLULAR LOCATION:Nucleus.||MISCELLANEOUS:Although strongly related to RNA-specific endonuclease proteins, it lacks the HXHXDH motif that binds zinc and participates in the catalytic center. Its function as endonuclease is therefore unsure.||SIMILARITY:Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.||SEQUENCE CAUTION:Sequence=AAB67601.1; Type=Erroneous gene model prediction;

Subcellular localization

Nucleus.

Gene name

integrator complex subunit 9

Protein sequence

MKLYCLSGHPTLPCNVLKFKSTTIMLDCGLDMTSTLNFLP LPLVQSPRLSNLPGWSLKDGNAFLDKELKECSGHVFVDS VPEFCLPETELIDLSTVDVILISNYHCMMALPYITEHTG FTGTVYATEPTVQIGRLLMEELVNFIERVPKAQSASLWK NKDIQRLLPSPLKDAVEVSTWRRCYTMQEVNSALSKIQL VGYSQKIELFGAVQVTPLSSGYALGSSNWIIQSHYEKVS YVSGSSLLTTHPQPMDQASLKNSDVLVLTGLTQIPTANP DGMVGEFCSNLALTVRNGGNVLVPCYPSGVIYDLLECLY QYIDSAGLSSVPLYFISPVANSSLEFSQIFAEWLCHNKQ SKVYLPEPPFPHAELIQTNKLKHYPSIHGDFSNDFRQPC VVFTGHPSLRFGDVVHFMELWGKSSLNTVIFTEPDFSYL EALAPYQPLAMKCIYCPIDTRLNFIQVSKLLKEVQPLHV VCPEQYTQPPPAQSHRMDLMIDCQPPAMSYRRAEVLALP FKRRYEKIEIMPELADSLVPMEIKPGISLATVSAVLHTK DNKHLLQPPPRPAQPTSGKKRKRVSDDVPDCKVLKPLLS GSIPVEQFVQTLEKHGFSDIKVEDTAKGHIVLLQEAETL IQIEEDSTHIICDNDEMLRVRLRDLVLKFLQKF

Database cross reference

RefSeq Protein accession:NP_001138631
RefSeq Protein gi:223555970

Liver relevance

HLPP validation

Yes/No

Yes

Project name

French Liver;

Ontology annotation

GO-C

GO:0032039;C:integrator complex;IDA:HGNC.

GO-F

GO:0005515;F:protein binding;IPI:UniProtKB.

GO-P

GO:0016180;P:snRNA processing;IDA:HGNC.