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Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr25338

Uniprot ID

IP3KC_HUMAN

Uniprot Acc

Q96DU7;Q9UE25;Q9Y475;

Protein name

Inositol-trisphosphate 3-kinase C

Comment

FUNCTION:Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate (By similarity).||CATALYTIC ACTIVITY:ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.||ENZYME REGULATION:Activated by calcium/calmodulin. Inhibited by high concentrations of the substrate Ins(1,2,4)P3, and allosterically activated by the product Ins(1,3,4,5)P4.||SUBCELLULAR LOCATION:Nucleus. Cytoplasm. Note=Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity.||TISSUE SPECIFICITY:Highly expressed in pancreas, skeletal muscle, liver, placenta and weakly in kidney and brain.||DISEASE:Defects in ITPKC are a cause of Kawasaki disease (KWD) [MIM:611775]; also known as mucocutaneous lymph node syndrome or infantile polyarteritis. Kawasaki disease is an acute, self- limited vasculitis of infants and children characterized by prolonged fever unresponsive to antibiotics, polymorphous skin rash, erythema of the oral

Subcellular localization

Nucleus.Cytoplasm.

Gene name

inositol-trisphosphate 3-kinase C

Protein sequence

MRRCPCRGSLNEAEAGALPAAARMGLEAPRGGRRRQPGQQ RPGPGAGAPAGRPEGGGPWARTEGSSLHSEPERAGLGPA PGTESPQAEFWTDGQTEPAAAGLGVETERPKQKTEPDRS SLRTHLEWSWSELETTCLWTETGTDGLWTDPHRSDLQFQ PEEASPWTQPGVHGPWTELETHGSQTQPERVKSWADNLW THQNSSSLQTHPEGACPSKEPSADGSWKELYTDGSRTQQ DIEGPWTEPYTDGSQKKQDTEAARKQPGTGGFQIQQDTD GSWTQPSTDGSQTAPGTDCLLGEPEDGPLEEPEPGELLT HLYSHLKCSPLCPVPRLIITPETPEPEAQPVGPPSRVEG GSGGFSSASSFDESEDDVVAGGGGASDPEDRSGSKPWKK LKTVLKYSPFVVSFRKHYPWVQLSGHAGNFQAGEDGRIL KRFCQCEQRSLEQLMKDPLRPFVPAYYGMVLQDGQTFNQ MEDLLADFEGPSIMDCKMGSRTYLEEELVKARERPRPRK DMYEKMVAVDPGAPTPEEHAQGAVTKPRYMQWRETMSST STLGFRIEGIKKADGTCNTNFKKTQALEQVTKVLEDFVD GDHVILQKYVACLEELREALEISPFFKTHEVVGSSLLFV HDHTGLAKVWMIDFGKTVALPDHQTLSHRLPWAEGNRED GYLWGLDNMICLLQGLAQS

Database cross reference

RefSeq Protein accession:NP_079470
RefSeq Protein gi:18643383

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell. GO:0005634;C:nucleus;IEA:UniProtKB-SubCell.

GO-F

GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0005516;F:calmodulin binding;IEA:UniProtKB-KW. GO:0008440;F:inositol trisphosphate 3-kinase activity;IEA:EC.

Pathway

Pathway name

Inositol_Phosphate_Metabolism