Protein basic information
| LiverAtlas Protein ID |
HuLPr25346 |
|
Uniprot ID |
|
|
Uniprot Acc |
Q8NFU5; |
|
Protein name |
Inositol polyphosphate multikinase |
|
Comment |
FUNCTION:Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol-1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4).||CATALYTIC ACTIVITY:ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate.||CATALYTIC ACTIVITY:ATP + 1D-myo-inositol 1,4,5,6- tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6- pentakisphosphate.||SUBCELLULAR LOCATION:Nucleus.||TISSUE SPECIFICITY:Ubiquitous, with the highest expression in skeletal muscle, liver, placenta, lung, peripheral blood leukocytes, kidney, spleen and colon.||SIMILARITY:Belongs to the inositol phosphokinase (IPK) family. |
|
Subcellular localization |
Nucleus. |
|
Gene name |
|
|
Protein sequence
|
MATEPPSPLRVEAPGPPEMRTSPAIESTPEGTPQPAGGRL RFLNGCVPLSHQVAGHMYGKDKVGILQHPDGTVLKQLQP PPRGPRELEFYNMVYAADCFDGVLLELRKYLPKYYGIWS PPTAPNDLYLKLEDVTHKFNKPCIMDVKIGQKSYDPFAS SEKIQQQVSKYPLMEEIGFLVLGMRVYHVHSDSYETENQ HYGRSLTKETIKDGVSRFFHNGYCLRKDAVAASIQKIEK ILQWFENQKQLNFYASSLLFVYEGSSQPTTTKLNDRTLA EKFLSKGQLSDTEVLEYNNNFHVLSSTANGKIESSVGKS LSKMYARHRKIYTKKHHSQTSLKVENLEQDNGWKSMSQE HLNGNVLSQLEKVFYHLPTGCQEIAEVEVRMIDFAHVFP SNTIDEGYVYGLKHLISVLRSILDN |
|
Database cross reference |
RefSeq Protein accession:NP_689416
|
Liver relevance
|
HLPP validation |
Yes/No |
Yes |
|
Project name |
Chinese Liver; |
Ontology annotation
| GO-C |
GO:0005634;C:nucleus;IEA:UniProtKB-SubCell. |
|
GO-F |
GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0000823;F:inositol trisphosphate 6-kinase activity;IEA:EC. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr25346 |
PHOSPHORYLATION |
412 |
S |
Phospho-ELM |
HTP |
N |
 
|
|
|
HuLPr25346 |
PHOSPHORYLATION |
7 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr25346 |
PHOSPHORYLATION |
350 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr25346 |
PHOSPHORYLATION |
21 |
T |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr25346 |
PHOSPHORYLATION |
22 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr25346 |
PHOSPHORYLATION |
27 |
S |
PhosphoSitePlus |
LTP HTP |
N |
|
|
|
HuLPr25346 |
PHOSPHORYLATION |
28 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr25346 |
PHOSPHORYLATION |
412 |
S |
PhosphoSitePlus |
LTP |
N |
|
Pathway
| Pathway name | |
| Pathway name |
