Choose one of the five choices you want to search:

Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr25359

Uniprot ID

IPPK_HUMAN

Uniprot Acc

Q9H8X2;Q5T9F7;Q9H7V8;

Protein name

Inositol-pentakisphosphate 2-kinase

Comment

FUNCTION:Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis.||CATALYTIC ACTIVITY:ATP + 1D-myo-inositol 1,3,4,5,6- pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate.||BIOPHYSICOCHEMICAL PROPERTIES:Kinetic parameters: KM=0.43 uM for Ins(1,3,4,5,6)P5; KM=21 uM for ATP; Vmax=31 nmol/min/mg enzyme;||SUBCELLULAR LOCATION:Cytoplasm (By similarity). Nucleus (By similarity).||TISSUE SPECIFICITY:Ubiquitously expressed, with high expression in heart, brain, testis and placenta.||DOMAIN:The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.||SIMILARITY:Belongs to the IPK1 type 2 family.||SEQUENCE CAUTION:Sequence=BAB14866.1; Type=Erroneous initiation; Sequence=CAI12593.1; Type=Erroneous gene model prediction;

Subcellular localization

Cytoplasm(By similarity).Nucleus(By similarity).

Gene name

inositol 1,3,4,5,6-pentakisphosphate 2-kinase

Protein sequence

MEEGKMDENEWGYHGEGNKSLVVAHAQRCVVLRFLKFPPN RKKTSEEIFQHLQNIVDFGKNVMKEFLGENYVHYGEVVQ LPLEFVKQLCLKIQSERPESRCDKDLDTLSGYAMCLPNL TRLQTYRFAEHRPILCVEIKPKCGFIPFSSDVTHEMKHK VCRYCMHQHLKVATGKWKQISKYCPLDLYSGNKQRMHFA LKSLLQEAQNNLKIFKNGELIYGCKDARSPVADWSELAH HLKPFFFPSNGLASGPHCTRAVIRELVHVITRVLLSGSD KGRAGTLSPGLGPQGPRVCEASPFSRSLRCQGKNTPERS GLPKGCLLYKTLQVQMLDLLDIEGLYPLYNRVERYLEEF PEERKTLQIDGPYDEAFYQKLLDLSTEDDGTVAFALTKV QQYRVAMTAKDCSIMIALSPCLQDASSDQRPVVPSSRSR FAFSVSVLDLDLKPYESIPHQYKLDGKIVNYYSKTVRAK DNAVMSTRFKESEDCTLVLHKV

Database cross reference

RefSeq Protein accession:NP_073592
RefSeq Protein gi:12232423

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell. GO:0005634;C:nucleus;IEA:UniProtKB-SubCell.

GO-F

GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0035299;F:inositol pentakisphosphate 2-kinase activity;IDA:HGNC.

GO-P

GO:0046853;P:inositol or phosphatidylinositol phosphorylation;IDA:HGNC.

Pathway

Pathway name

Inositol_Phosphate_Metabolism