HuLPr25376

Uniprot ID

IQEC1_HUMAN

Uniprot Acc

Q6DN90;O94863;Q96D85;

Protein name

IQ motif and SEC7 domain-containing protein 1

Comment

FUNCTION:In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin.||SUBUNIT:Interacts with ARF6.||SUBCELLULAR LOCATION:Cytoplasm. Nucleus. Note=At steady state, may be preferentially cytosolic.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=BRAG2b; IsoId=Q6DN90-1; Sequence=Displayed; Name=2; Synonyms=BRAG2a; IsoId=Q6DN90-2; Sequence=VSP 019758; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Expressed in brain, ovary, heart, lung, liver, kidney and leukocytes. Moderate expression was also detected in lung, skeletal muscle, placenta, small intestine, pancreas, spleen and testis.||SIMILARITY:Belongs to the BRAG family.||SIMILARITY:Contains 1 IQ domain.||SIMILARITY:Contains 1 PH domain.||SIMILARITY:Contains 1 SEC7 domain.

Subcellular localization

Cytoplasm.Nucleus.

Gene name

IQ motif and Sec7 domain 1

Protein sequence

MWCLHCNSERTQSLLELELDSGVEGEAPSSETGTSLDSPS AYPQGPLVPGSSLSPDHYEHTSVGAYGLYSGPPGQQQRT RRPKLQHSTSILRKQAEEEAIKRSRSLSESYELSSDLQD KQVEMLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERL RSSMSENRMSRRIVLSNMRMQFSFEGPEKVHSSYFEGKQ VSVTNDGSQLGALVSPECGDLSEPTTLKSPAPSSDFADA ITELEDAFSRQVKSLAESIDDALNCRSLHTEEAPALDAA RARDTEPQTALHGMDHRKLDEMTASYSDVTLYIDEEELS PPLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAHKEDK ADTDTSCRSTPSLERQEQRLRVEHLPLLTIEPPSDSSVD LSDRSERGSLKRQSAYERSLGGQQGSPKHGPHSGAPKSL PREEPELRPRPPRPLDSHLAINGSANRQSKSESDYSDGD NDSINSTSNSNDTINCSSESSSRDSLREQTLSKQTYHKE ARNSWDSPAFSNDVIRKRHYRIGLNLFNKKPEKGVQYLI ERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFN RDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVE RLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILLNT DMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGI YERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGL GCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLF NDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQY YPNGIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRE SIAEVQEMEKHRIESELEKQKGVVRPSMSQCSSLKKESG NGTLSRACLDDSYASGEGLKRSALSSSLRDLSEAGKRGR RSSAGSLESNVEFQPFEPLQPSVLCS

Database cross reference

RefSeq Protein accession:NP_001127854
RefSeq Protein gi:197304786

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0005737;C:cytoplasm;ISS:RefGenome. GO:0005634;C:nucleus;IEA:UniProtKB-SubCell.

GO-F

GO:0005086;F:ARF guanyl-nucleotide exchange factor activity;ISS:RefGenome.

GO-P

GO:0032012;P:regulation of ARF protein signal transduction;IEA:InterPro.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr25376

PHOSPHORYLATION

362

T

Phospho-ELM

6163

HTP

N

HuLPr25376

PHOSPHORYLATION

180

S

Phospho-ELM

36133

HTP

N

HuLPr25376

PHOSPHORYLATION

512

S

Phospho-ELM

36134

HTP

yes

HuLPr25376

PHOSPHORYLATION

512

S

PhosphoSitePlus

3202419

HTP

yes

HuLPr25376

PHOSPHORYLATION

109

S

PhosphoSitePlus

4692919

LTP

N

HuLPr25376

PHOSPHORYLATION

89

S

PhosphoSitePlus

3823035

HTP

N

HuLPr25376

PHOSPHORYLATION

343

Y

PhosphoSitePlus

3453069

LTP

N

HuLPr25376

PHOSPHORYLATION

515

S

PhosphoSitePlus

481466

LTP

N

HuLPr25376

PHOSPHORYLATION

925

S

PhosphoSitePlus

481468

LTP

N

HuLPr25376

PHOSPHORYLATION

105

S

PhosphoSitePlus

2024889

LTP

N

HuLPr25376

PHOSPHORYLATION

362

T

PhosphoSitePlus

453637

LTP

N

HuLPr25376

PHOSPHORYLATION

180

S

PhosphoSitePlus

469657

LTP

N

HuLPr25376

PHOSPHORYLATION

911

Y

PhosphoSitePlus

472858

LTP

HTP

N

Arf6_signaling_events